| CD36 (thrombospondin receptor) expression in childhood acute megakaryoblastic leukemia: in vitro drug sensitivity and outcome. | |
MedLine Citation:
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PMID: 17071479 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The outcome for children with acute megakaryoblastic leukemia (AMKL) remains poor, except for cases associated with Down syndrome (DS). This study compared immunophenotypic and drug sensitivity patterns of childhood AMKL cases with or without DS. All DS-AMKL cases showed high expression of CD36 and were very sensitive to cytarabine and daunorubicin in vitro. In children without DS, high expression of CD36 on AMKL blasts identified a sub-group with immunophenotypic and drug sensitivity patterns similar to that of DS AMKL. Among non-DS AMKL patients, CD36-high cases had a superior outcome compared with CD36-negative cases. CD36 expression in acute myeloid leukemia cases other than AMKL was not associated with increased in vitro drug sensitivity. CD36 expression in AMKL may be an indicator of megakaryoblast maturation and chemotherapy sensitivity. |
Authors:
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Süreyya Savaşan; Steven Buck; Susana C Raimondi; David L Becton; Howard Weinstein; Myron Chang; Yaddanapudi Ravindranath |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Leukemia & lymphoma Volume: 47 ISSN: 1042-8194 ISO Abbreviation: Leuk. Lymphoma Publication Date: 2006 Oct |
Date Detail:
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Created Date: 2006-10-30 Completed Date: 2007-01-17 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9007422 Medline TA: Leuk Lymphoma Country: England |
Other Details:
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Languages: eng Pagination: 2076-83 Citation Subset: IM |
Affiliation:
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Children's Hospital of Michigan, Division of Hematology/Oncology, Carman Ann Adams Department of Pediatrics, Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA. ssavasan@med.wayne.edu |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Antigens, CD36 / biosynthesis* Cell Membrane / metabolism Child Child, Preschool Cytarabine / pharmacology Daunorubicin / pharmacology Down Syndrome / complications Gene Expression Regulation, Neoplastic* Humans Immunophenotyping Infant Infant, Newborn Leukemia, Megakaryoblastic, Acute / complications*, metabolism*, pathology Sensitivity and Specificity Treatment Outcome Tumor Markers, Biological |
| Grant Support | |
ID/Acronym/Agency:
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CA-21765/CA/NCI NIH HHS; U10 CA 30969/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD36; 0/Tumor Markers, Biological; 147-94-4/Cytarabine; 20830-81-3/Daunorubicin |
| Comments/Corrections | |
Comment In:
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Leuk Lymphoma. 2006 Oct;47(10):2004-5
[PMID:
17071466
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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