Document Detail


CD36 (thrombospondin receptor) expression in childhood acute megakaryoblastic leukemia: in vitro drug sensitivity and outcome.
MedLine Citation:
PMID:  17071479     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The outcome for children with acute megakaryoblastic leukemia (AMKL) remains poor, except for cases associated with Down syndrome (DS). This study compared immunophenotypic and drug sensitivity patterns of childhood AMKL cases with or without DS. All DS-AMKL cases showed high expression of CD36 and were very sensitive to cytarabine and daunorubicin in vitro. In children without DS, high expression of CD36 on AMKL blasts identified a sub-group with immunophenotypic and drug sensitivity patterns similar to that of DS AMKL. Among non-DS AMKL patients, CD36-high cases had a superior outcome compared with CD36-negative cases. CD36 expression in acute myeloid leukemia cases other than AMKL was not associated with increased in vitro drug sensitivity. CD36 expression in AMKL may be an indicator of megakaryoblast maturation and chemotherapy sensitivity.
Authors:
Süreyya Savaşan; Steven Buck; Susana C Raimondi; David L Becton; Howard Weinstein; Myron Chang; Yaddanapudi Ravindranath
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Leukemia & lymphoma     Volume:  47     ISSN:  1042-8194     ISO Abbreviation:  Leuk. Lymphoma     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-10-30     Completed Date:  2007-01-17     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9007422     Medline TA:  Leuk Lymphoma     Country:  England    
Other Details:
Languages:  eng     Pagination:  2076-83     Citation Subset:  IM    
Affiliation:
Children's Hospital of Michigan, Division of Hematology/Oncology, Carman Ann Adams Department of Pediatrics, Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA. ssavasan@med.wayne.edu
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Antigens, CD36 / biosynthesis*
Cell Membrane / metabolism
Child
Child, Preschool
Cytarabine / pharmacology
Daunorubicin / pharmacology
Down Syndrome / complications
Gene Expression Regulation, Neoplastic*
Humans
Immunophenotyping
Infant
Infant, Newborn
Leukemia, Megakaryoblastic, Acute / complications*,  metabolism*,  pathology
Sensitivity and Specificity
Treatment Outcome
Tumor Markers, Biological
Grant Support
ID/Acronym/Agency:
CA-21765/CA/NCI NIH HHS; U10 CA 30969/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Antigens, CD36; 0/Tumor Markers, Biological; 147-94-4/Cytarabine; 20830-81-3/Daunorubicin
Comments/Corrections
Comment In:
Leuk Lymphoma. 2006 Oct;47(10):2004-5   [PMID:  17071466 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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