Document Detail

CD36 mediates the phagocytosis of Plasmodium falciparum-infected erythrocytes by rodent macrophages.
MedLine Citation:
PMID:  14722884     Owner:  NLM     Status:  MEDLINE    
Phagocytic cells represent an important line of innate defense against malaria; however, little is known of the mechanism by which macrophages recognize Plasmodium falciparum-parasitized erythrocytes (PEs). Using macrophages from CD36 wild-type (WT), CD36-null, and CD36 transgenically-rescued rodents, we demonstrate a major role for CD36 in the phagocytosis of PEs. WT macrophages display enhanced phagocytic capacity for nonopsonized PEs, compared with that for CD36-null mouse and rat macrophages. Transgenic rescue of CD36-deficient rats restored macrophage phagocytic capacity for PEs. CD36 receptor blockade with monoclonal antibodies and proteolytic cleavage of CD36 ligands from the surface of PEs inhibited the uptake of PEs. Up-regulation of rodent CD36 by use of peroxisome proliferator-activated receptor (PPARgamma) agonists increased the phagocytosis of PEs. CD36-mediated uptake of PEs did not result in increased tumor necrosis factor-alpha secretion, of which high levels are associated with adverse outcomes in malaria. These studies support the use of these rodent models to examine PE-CD36 interactions.
Samir N Patel; Lena Serghides; Todd G Smith; Maria Febbraio; Roy L Silverstein; Theodore W Kurtz; Michal Pravenec; Kevin C Kain
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2004-01-09
Journal Detail:
Title:  The Journal of infectious diseases     Volume:  189     ISSN:  0022-1899     ISO Abbreviation:  J. Infect. Dis.     Publication Date:  2004 Jan 
Date Detail:
Created Date:  2004-01-14     Completed Date:  2004-02-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0413675     Medline TA:  J Infect Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  204-13     Citation Subset:  AIM; IM    
Department of Medicine, University of Toronto, Ontario, Canada.
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MeSH Terms
Antigens, CD36 / physiology*
Erythrocytes / parasitology*
Interleukin-6 / biosynthesis
Macrophages / immunology*
Mice, Inbred BALB C
Mice, Inbred C57BL
Plasmodium falciparum / immunology*
Rats, Inbred SHR
Rats, Inbred WKY
Receptors, Cytoplasmic and Nuclear / physiology
Receptors, Retinoic Acid / physiology
Retinoid X Receptors
Transcription Factors / physiology
Tumor Necrosis Factor-alpha / biosynthesis
Reg. No./Substance:
0/Antigens, CD36; 0/Interleukin-6; 0/Receptors, Cytoplasmic and Nuclear; 0/Receptors, Retinoic Acid; 0/Retinoid X Receptors; 0/Transcription Factors; 0/Tumor Necrosis Factor-alpha

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