| CD34+ immune suppressive cells in the peripheral blood of patients with head and neck cancer. | |
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MedLine Citation:
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PMID: 10961808 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Patients with head and neck squamous cell carcinoma (HNSCC) have profound defects in their immune defenses. Using immunofluorescent staining and flow cytometric analysis, we found that most patients with HNSCC have increased levels of CD34+ cells within their peripheral blood. These circulating CD34+ cells contribute to the depressed functional competence of the peripheral blood T-lymphocytes. This was demonstrated by the increased level of proliferative responsiveness to interleukin-2 by the patients' peripheral blood T-cells after depletion of CD34+ cells. These results show the importance of CD34+ cells in contributing to the depression of T-lymphocyte function in patients with HNSCC and suggest that strategies designed to reduce the levels of circulating CD34+ cells may enhance the immune reactivity of the patients' circulating T-lymphocytes against the HNSCC. |
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Authors:
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R Pandit; D M Lathers; N M Beal; T Garrity; M R Young |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Annals of otology, rhinology, and laryngology Volume: 109 ISSN: 0003-4894 ISO Abbreviation: Ann. Otol. Rhinol. Laryngol. Publication Date: 2000 Aug |
Date Detail:
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Created Date: 2000-09-07 Completed Date: 2000-09-07 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0407300 Medline TA: Ann Otol Rhinol Laryngol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 749-54 Citation Subset: AIM; IM |
Affiliation:
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Department of Otolaryngology-Head and Neck Surgery, Loyola University Stritch School of Medicine, Maywood, Illinois, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antigens, CD34
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immunology* Blood Cell Count Blood Cells / immunology* Blood Component Removal Carcinoma, Squamous Cell / blood*, immunology*, pathology Head and Neck Neoplasms / blood*, immunology*, pathology Humans Immune System / pathology, physiopathology* T-Lymphocytes / immunology |
| Grant Support | |
ID/Acronym/Agency:
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CA-45080/CA/NCI NIH HHS; CA-48080/CA/NCI NIH HHS; CA-77208/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD34 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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