Document Detail


CD34+ immune suppressive cells in the peripheral blood of patients with head and neck cancer.
MedLine Citation:
PMID:  10961808     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Patients with head and neck squamous cell carcinoma (HNSCC) have profound defects in their immune defenses. Using immunofluorescent staining and flow cytometric analysis, we found that most patients with HNSCC have increased levels of CD34+ cells within their peripheral blood. These circulating CD34+ cells contribute to the depressed functional competence of the peripheral blood T-lymphocytes. This was demonstrated by the increased level of proliferative responsiveness to interleukin-2 by the patients' peripheral blood T-cells after depletion of CD34+ cells. These results show the importance of CD34+ cells in contributing to the depression of T-lymphocyte function in patients with HNSCC and suggest that strategies designed to reduce the levels of circulating CD34+ cells may enhance the immune reactivity of the patients' circulating T-lymphocytes against the HNSCC.
Authors:
R Pandit; D M Lathers; N M Beal; T Garrity; M R Young
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Annals of otology, rhinology, and laryngology     Volume:  109     ISSN:  0003-4894     ISO Abbreviation:  Ann. Otol. Rhinol. Laryngol.     Publication Date:  2000 Aug 
Date Detail:
Created Date:  2000-09-07     Completed Date:  2000-09-07     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0407300     Medline TA:  Ann Otol Rhinol Laryngol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  749-54     Citation Subset:  AIM; IM    
Affiliation:
Department of Otolaryngology-Head and Neck Surgery, Loyola University Stritch School of Medicine, Maywood, Illinois, USA.
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MeSH Terms
Descriptor/Qualifier:
Antigens, CD34 / immunology*
Blood Cell Count
Blood Cells / immunology*
Blood Component Removal
Carcinoma, Squamous Cell / blood*,  immunology*,  pathology
Head and Neck Neoplasms / blood*,  immunology*,  pathology
Humans
Immune System / pathology,  physiopathology*
T-Lymphocytes / immunology
Grant Support
ID/Acronym/Agency:
CA-45080/CA/NCI NIH HHS; CA-48080/CA/NCI NIH HHS; CA-77208/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Antigens, CD34

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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