Document Detail


CD34(+) fibrocytes in melanocytic nevi and malignant melanomas of the skin.
MedLine Citation:
PMID:  18813945     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CD34(+) fibrocytes are constitutive elements of the human connective tissue. The stroma associated with invasive carcinomas is characterized by a stereotypic loss of CD34(+) fibrocytes and a phenotype change towards CD34(-) alpha-Smooth muscle actin (SMA)(+) myofibroblasts. Secreted protein acidic and rich in cysteine (SPARC) is an important mediator of tumor-associated stromal remodeling. Melanocytic lesions of the skin have not been investigated as to this aspect up to now. Thus, we investigated a total of 20 malignant melanomas and 29 melanocytic nevi. The normal dermis and benign melanocytic nevi showed numerous CD34(+) fibrocytes, whereas malignant melanomas were devoid of this cell type. alpha-SMA-positive myofibroblasts were absent from the normal dermis, melanocytic nevi, and malignant melanomas. SPARC was positive in malignant melanoma cells and negative in their associated stroma, while all melanocytic nevi were completely negative. The stromal phenotype of malignant melanomas (CD34(-) alpha-SMA(-)) differs from that of invasive carcinomas (CD34(-) alpha-SMA(+)) suggesting different pathogenic mechanisms involved in tumor-associated stromal remodeling. SPARC expression appears to be closely related to malignancy in melanocytic lesions.
Authors:
Cordula Wessel; Christina C Westhoff; Katharina Nowak; Ingrid Moll; Peter J Barth
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Publication Detail:
Type:  Journal Article     Date:  2008-09-24
Journal Detail:
Title:  Virchows Archiv : an international journal of pathology     Volume:  453     ISSN:  0945-6317     ISO Abbreviation:  Virchows Arch.     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-10-21     Completed Date:  2009-02-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9423843     Medline TA:  Virchows Arch     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  485-9     Citation Subset:  IM    
Affiliation:
Department of Dermatology and Venerology, University Hospital Hamburg-Eppendorf, Hamburg, Germany.
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MeSH Terms
Descriptor/Qualifier:
Actins / metabolism
Antigens, CD34 / metabolism*
Connective Tissue / metabolism*,  pathology*
Cysteine / metabolism
Humans
Melanoma / metabolism,  pathology*
Nevus, Pigmented / metabolism,  pathology*
Osteonectin / metabolism
Phenotype
Retrospective Studies
Skin Neoplasms / metabolism,  pathology*
Chemical
Reg. No./Substance:
0/Actins; 0/Antigens, CD34; 0/Osteonectin; 52-90-4/Cysteine

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