Document Detail


CD34 expression is associated with major adverse prognostic factors in adult acute lymphoblastic leukemia.
MedLine Citation:
PMID:  7532767     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Seventy-five adult patients with newly diagnosed acute lymphoblastic leukemia (ALL) were analyzed for CD34 expression on leukemic cells. CD34 was significantly associated with B-cell lineage ALL (p = 0.0002). In B-lineage ALL, CD34 positivity was significantly associated with expressions of CD9 (p = 0.001), CD19 (p = 0.00001) and CD22 (p = 0.002). CD34 was more expressed in B-ALLs with higher WBC cell count (p = 0.04), and higher percentage of peripheral blood leukemic cells (p = 0.005), total or partial monosomy of chromosome 7 (p = 0.0001) or Ph+ chromosome (p = 0.01); and less expressed in cases with hyperdiploidy (> or = 50 chromosomes) (p = 0.03). CD34 was more expressed in poor risk B-ALLs patients, defined according to Hoelzer criteria (p = 0.01). In T-lineage ALL, CD34 positivity was inversely correlated with the expression of CD10 (p = 0.05). After intensive induction therapy, 58 of 73 evaluable patients (79%) achieved a complete remission (CR). CD34 positivity was correlated with the persistence of blast cells in day 15 bone marrow aspirates (p = 0.001) and after one course of induction chemotherapy (p = 0.01). With a median follow-up of 11 months, no statistical differences were seen in leukemia-free survival and overall survival between CD34 positive and negative cases, even when stratifying by immunophenotype. We conclude that CD34 expression is associated with features of poor prognosis in adult ALL. Its study might therefore become useful in the design of future prognostic models.
Authors:
X Thomas; E Archimbaud; C Charrin; J P Magaud; D Fiere
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Leukemia     Volume:  9     ISSN:  0887-6924     ISO Abbreviation:  Leukemia     Publication Date:  1995 Feb 
Date Detail:
Created Date:  1995-03-30     Completed Date:  1995-03-30     Revised Date:  2013-03-04    
Medline Journal Info:
Nlm Unique ID:  8704895     Medline TA:  Leukemia     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  249-53     Citation Subset:  IM    
Affiliation:
Service d'Hématologie, Hôpital Edouard Herriot, Lyon, France.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Amsacrine / administration & dosage
Aneuploidy
Antibiotics, Antineoplastic / administration & dosage
Antigens, CD / analysis*
Antigens, CD34
Antigens, Neoplasm / analysis*
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Asparaginase / administration & dosage
Bone Marrow Transplantation
Burkitt Lymphoma / blood*,  genetics,  mortality
Cell Differentiation
Chromosome Aberrations
Combined Modality Therapy
Cyclophosphamide / administration & dosage
Cytarabine / administration & dosage
Disease-Free Survival
Female
Humans
Immunophenotyping
Life Tables
Logistic Models
Male
Middle Aged
Neoplastic Stem Cells / chemistry*
Precursor Cell Lymphoblastic Leukemia-Lymphoma / blood*,  genetics,  mortality,  therapy
Prednisone / administration & dosage
Prognosis
Proportional Hazards Models
Remission Induction
Risk Factors
Salvage Therapy
Survival Analysis
Tumor Markers, Biological / blood*
Vincristine / administration & dosage
Chemical
Reg. No./Substance:
0/Antibiotics, Antineoplastic; 0/Antigens, CD; 0/Antigens, CD34; 0/Antigens, Neoplasm; 0/Tumor Markers, Biological; 147-94-4/Cytarabine; 50-18-0/Cyclophosphamide; 51264-14-3/Amsacrine; 53-03-2/Prednisone; 57-22-7/Vincristine; EC 3.5.1.1/Asparaginase

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