Document Detail


CD30 serum levels and response to hymenoptera venom immunotherapy.
MedLine Citation:
PMID:  18714536     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The glycoprotein CD30 is expressed and released by T lymphocytes that secrete type 2 helper cytokines of (T(H)2). These molecules play a role in the pathogenesis of allergic diseases. Venom immunotherapy has proven to be very effective in hymenoptera venom allergy through a shift in cytokine production from T(H)2-type cytokines to T(H)1-type cytokines.
OBJECTIVE: To evaluate the relationship between the soluble form of CD30 (sCD30) and venom immunotherapy in patients with hymenoptera venom allergy.
MATERIALS AND METHODS: sCD30 levels were assayed by enzyme-linked immunosorbent assay in the sera of 61 healthy controls and 14 patients with hymenoptera venom allergy who had undergone immunotherapy before treatment and 1,3, and 12 months after treatment started. Nine patients were allergic to Apis venom, 4 to Vespula venom, and 1 to Polistes venom.
RESULTS: CD30 serum levels (median, interquartile range) were significantly higher in venom-allergic patients before treatment (33.6 U/mL; 14.8-61.6) than in controls (9.7 U/mL, 1.9-21.3) (P < .000). These levels decreased progressively during treatment in all patients except 2 (P < .000). At the third month of therapy, the levels reached statistical significance in comparison with baseline.
CONCLUSIONS: This study shows that sCD30 levels are significantly higher in patients with hymenoptera venom allergy and indirectly confirms a preferential T(H)2-type cytokine production in these patients. sCD30 expression decreases during immunotherapy, thus confirming the immunomodulatory role of this treatment in promoting a shift to T(H)1-type cytokines.
Authors:
F G Foschi; F Emiliani; S Savini; O Quercia; G F Stefanini
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of investigational allergology & clinical immunology     Volume:  18     ISSN:  1018-9068     ISO Abbreviation:  J Investig Allergol Clin Immunol     Publication Date:  2008  
Date Detail:
Created Date:  2008-08-21     Completed Date:  2008-10-06     Revised Date:  2013-07-31    
Medline Journal Info:
Nlm Unique ID:  9107858     Medline TA:  J Investig Allergol Clin Immunol     Country:  Spain    
Other Details:
Languages:  eng     Pagination:  279-83     Citation Subset:  IM    
Affiliation:
Allergic Unit, Internal Medicine Department, Faenza Hospital, Faenza, RA, Italy. fg.foschi@ausl.ra.it
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Animals
Antigens, CD30 / blood*
Arthropod Venoms / immunology*
Desensitization, Immunologic*
Female
Humans
Hymenoptera / immunology*
Hypersensitivity, Immediate / immunology*,  therapy
Insect Bites and Stings / immunology
Male
Middle Aged
Th1 Cells / immunology,  metabolism
Th2 Cells / immunology,  metabolism
Chemical
Reg. No./Substance:
0/Antigens, CD30; 0/Arthropod Venoms

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