Document Detail


CD30+ cells in regressing keratoacanthoma and in non-keratoacanthomatous squamous cell carcinoma.
MedLine Citation:
PMID:  19205562     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In a previous report, we demonstrated how a percentage of CD30+ cells was nearly constant in the inflammatory infiltrate that accompanies keratoacanthoma (KA), but we saw a lack of CD30 cells when KA was regressing. In the current study we investigated the presence of CD30+ cells in the inflammatory infiltrate of regressing KA as well as in well-differentiated squamous cell carcinomas of non-keratoacanthomatous type. We examined 80 keratoacanthomas from our archives, and selected those with the pattern of advanced regression. We also examined 14 well-differentiated non-KA type SCCs from our archives. In all the cases, we performed a immunohistochemical study for CD30. Of the 80 KAs, 6 cases (7.5%) showed the pattern of regression. While the mean of the percentages of CD30+ cells in the infiltrate was 0.58 for the regressing KAs, it was 1.77 for SCCs. While cells with the paranuclear-dot pattern of immunostaining plus membranous pattern of immunostaining could be easily found in SCC cases, cells only with membranous expression of the marker were the rule in KA. We conclude that CD30 positive cells might play a role in KA regression (Tab. 2, Fig. 4, Ref. 24).
Authors:
A Fernandez-Flores
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Bratislavské lekárske listy     Volume:  109     ISSN:  0006-9248     ISO Abbreviation:  Bratisl Lek Listy     Publication Date:  2008  
Date Detail:
Created Date:  2009-02-11     Completed Date:  2009-03-05     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0065324     Medline TA:  Bratisl Lek Listy     Country:  Slovakia    
Other Details:
Languages:  eng     Pagination:  508-12     Citation Subset:  IM    
Affiliation:
The Service of Anatomic Pathology, Hospital El Bierzo, and the Service of Cellular Pathology, Clinica Ponferrada, Ponferrada, Spain. gpyauflowerlion@terra.es
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Antigens, CD30 / analysis*
Carcinoma, Squamous Cell / immunology*,  pathology
Female
Humans
Immunohistochemistry
Keratoacanthoma / immunology,  pathology
Male
Middle Aged
Remission Induction
Skin Diseases / immunology,  pathology
Skin Neoplasms / immunology*,  pathology
Chemical
Reg. No./Substance:
0/Antigens, CD30

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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