Document Detail


CD28-Specific Immunomodulating Antibodies: What Can Be Learned From Experimental Models?
MedLine Citation:
PMID:  22471377     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Tolerance induction to alloantigens remains a major challenge in transplant immunology. Progress in the last decade of our understanding of T-cell activation has led to the development of new immunotherapeutic strategies to replace conventional immunosuppression which inhibits the immune system in a nonspecific way. In particular, positive and negative costimulatory molecules of the CD28 family have been consistently demonstrated to be critical for the development of productive immune responses as well as the establishment and maintenance of peripheral tolerance. However, recent discoveries of novel costimulatory interactions confer a novel dimension to the immunoregulatory interactions within the B7:CD28 family and compels a revised view within a "quintet" of costimulatory molecules: CD28/B7/CTLA-4/PD-L1/ICOSL. Complexity introduced in this more detailed costimulatory pathway has important implications in therapeutic interventions against human immunological diseases and, especially, highlight the fundamental differences in selectively targeting CD28 molecules instead of B7 counterparts. In this review, we discuss these differences and emphasize different CD28-specific immunomodulating strategies evaluated in experimental models of transplantation and autoimmune diseases.
Authors:
N Poirier; G Blancho; B Vanhove
Related Documents :
24516597 - The sulfated laminarin triggers a stress transcriptome before priming the sa- and ros-d...
15972887 - Androgens augment the mitogenic effects of oocyte-secreted factors and growth different...
24246617 - Strategies used by yersinia enterocolitica to evade killing by the host: thinking beyon...
23162557 - Application of tissue engineering to the immune system: development of artificial lymph...
11035077 - Reciprocal expression of the tnf family receptor herpes virus entry mediator and its li...
16505057 - Inhibition of apoptosis and reduction of intracellular ph decrease in retinal neural ce...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-4
Journal Detail:
Title:  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons     Volume:  -     ISSN:  1600-6143     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100968638     Medline TA:  Am J Transplant     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© Copyright 2012 The American Society of Transplantation and the American Society of Transplant Surgeons.
Affiliation:
Institut National de la Santé Et de la Recherche Médicale Unité Mixte de Recherche 1064, Nantes, France Institut de Transplantation Urologie Néphrologie (ITUN), Université de Nantes, Nantes F44000, France Effimune SAS, Nantes, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Discovery of Novel Urea-Based Hepatitis C Protease Inhibitors with High Potency against Protease-Inh...
Next Document:  Monitoring physical functioning as the sixth vital sign: evaluating patient and practice engagement ...