Document Detail

CD28 and ICOS play complementary non-overlapping roles in the development of Th2 immunity in vivo.
MedLine Citation:
PMID:  19646680     Owner:  NLM     Status:  MEDLINE    
Previous work has shown ICOS can function independently of CD28, but whether either molecule can compensate for the other in vivo is not known. Since ICOS is a potent inducer of Th2 cytokines and linked to allergy and elevated serum IgE in humans, we hypothesized that augmenting ICOS costimulation in murine allergic airway disease may overcome CD28 deficiency. While ICOS was expressed on T cells from CD28(-/-) mice, Th2-mediated airway inflammation was not induced in CD28(-/-) mice by increased ICOS costimulation. Further, we determined if augmenting CD28 costimulation could compensate for ICOS deficiency. ICOS(-/-) mice had a defect in airway eosinophilia that was not overcome by augmenting CD28 costimulation. CD28 costimulation also did not fully compensate for ICOS for antibody responses, germinal center formation or the development of follicular B helper T cells. CD28 and ICOS play complementary non-overlapping roles in the development of Th2 immunity in vivo.
Rebecca A Shilling; Bryan S Clay; Amanda G Tesciuba; Elizabeth L Berry; Tiffany Lu; Tamson V Moore; Hozefa S Bandukwala; Jiankun Tong; Joel V Weinstock; Richard A Flavell; Tom Horan; Steve K Yoshinaga; Andrew A Welcher; Judy L Cannon; Anne I Sperling
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2009-07-10
Journal Detail:
Title:  Cellular immunology     Volume:  259     ISSN:  1090-2163     ISO Abbreviation:  Cell. Immunol.     Publication Date:  2009  
Date Detail:
Created Date:  2009-09-21     Completed Date:  2009-10-07     Revised Date:  2014-09-24    
Medline Journal Info:
Nlm Unique ID:  1246405     Medline TA:  Cell Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  177-84     Citation Subset:  IM    
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MeSH Terms
Antigens, CD28 / immunology*
Antigens, Differentiation, T-Lymphocyte / immunology*
Bronchoalveolar Lavage Fluid / immunology
Disease Models, Animal
Enzyme-Linked Immunosorbent Assay
Flow Cytometry
Immunity, Cellular / immunology
Immunoglobulin E / blood
Inducible T-Cell Co-Stimulator Protein
Lung Diseases / immunology*
Mice, Inbred C57BL
Mice, Knockout
Specific Pathogen-Free Organisms
Th2 Cells / immunology*
Grant Support
K08 AI 059105/AI/NIAID NIH HHS; K08 AI059105/AI/NIAID NIH HHS; K08 AI059105-01A2/AI/NIAID NIH HHS; K08 AI059105-02/AI/NIAID NIH HHS; K08 AI059105-03/AI/NIAID NIH HHS; K08 AI059105-04/AI/NIAID NIH HHS; L30 RR021946/RR/NCRR NIH HHS; L30 RR021946-01/RR/NCRR NIH HHS; L30 RR021946-02/RR/NCRR NIH HHS; M01 RR000055/RR/NCRR NIH HHS; M01 RR000055-440830/RR/NCRR NIH HHS; M01 RR000055-458622/RR/NCRR NIH HHS; M01 RR000055-466670/RR/NCRR NIH HHS; P01 AI056352/AI/NIAID NIH HHS; P01 AI056352-010001/AI/NIAID NIH HHS; P01 AI56352/AI/NIAID NIH HHS; R01 AI050180/AI/NIAID NIH HHS; R01 AI050180-01/AI/NIAID NIH HHS; R01 AI050180-02/AI/NIAID NIH HHS; R01 AI050180-03/AI/NIAID NIH HHS; R01 AI050180-04/AI/NIAID NIH HHS; R01 AI050180-05/AI/NIAID NIH HHS; R01 AI50180/AI/NIAID NIH HHS; U54 AI057153/AI/NIAID NIH HHS; U54 AI057153-019003/AI/NIAID NIH HHS; U54 AI057153-05S19003/AI/NIAID NIH HHS
Reg. No./Substance:
0/Antigens, CD28; 0/Antigens, Differentiation, T-Lymphocyte; 0/ICOS protein, human; 0/Icos protein, mouse; 0/Inducible T-Cell Co-Stimulator Protein; 37341-29-0/Immunoglobulin E

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