Document Detail


CD26 and CD30 expression on the surface of lymphocyte during normal pregnancy.
MedLine Citation:
PMID:  11549856     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
It is increasingly apparent that the Th1/Th2 cell ratio is decreased during pregnancy. In a previous study, we revealed that combined analysis of soluble CD26 and CD30 might be a potent surrogate tool for evaluating the Th1/Th2 balance during pregnancy. Therefore, in the present study, we elucidated whether the CD26 and CD30 expression on the surface of lymphocyte is useful marker for Th1 and Th2 lymphocytes, respectively, during pregnancy with flow cytometric technique. The peripheral blood samples were obtained from 6 non-pregnant healthy women, 8 healthy pregnant women in the first trimester and 12 pregnant women in the third trimester. The mean percentages of CD26 expression did not differ significantly among these groups (p = 0.45). Also, the mean percentages of CD30 expression did not differ significantly among these groups (p = 0.32). From the present study, the expression of CD26 and CD30 did not appear to be a useful marker for Th1 and Th2 lymphocytes during pregnancy.
Authors:
K Hoshimoto; M Hayashi; T Ohkura
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Gynecologic and obstetric investigation     Volume:  52     ISSN:  0378-7346     ISO Abbreviation:  Gynecol. Obstet. Invest.     Publication Date:  2001  
Date Detail:
Created Date:  2001-09-10     Completed Date:  2001-12-04     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7900587     Medline TA:  Gynecol Obstet Invest     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  9-12     Citation Subset:  IM    
Copyright Information:
Copyright 2001 S. Karger AG, Basel
Affiliation:
Department of Obstetrics and Gynecology, Koshigaya Hospital, Dokkyo University School of Medicine, Minami-Koshigaya, Koshigaya, Saitama, Japan. hkazu@dokkyomed.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Adult
Antigens, CD26 / blood*
Antigens, CD30 / blood*
Female
Flow Cytometry
Gestational Age
Humans
Immunohistochemistry
Lymphocytes / blood*
Pregnancy / blood*
Reference Values
Th1 Cells / metabolism
Th2 Cells / metabolism
Chemical
Reg. No./Substance:
0/Antigens, CD30; EC 3.4.14.5/Antigens, CD26

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