| CD20-positive infiltrates in renal allograft biopsies with acute cellular rejection are not associated with worse graft survival. | |
| | |
MedLine Citation:
|
PMID: 17617861 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We examined rejection outcome and graft survival in 58 adult patients with acute cellular rejection Banff type I (ARI) or II (ARII), within 1 year after transplantation, with or without CD20-positive infiltrates. Antibody-mediated rejection was not examined. Of the 74 allograft biopsies, performed from 1999 to 2001, 40 biopsies showed ARI and 34 biopsies showed ARII; 30% of all the biopsies showed CD20-positive clusters with more than 100 cells, 9% with more than 200 cells and 5% with more than 275 cells. Patients with B cell-rich (>100 or >200/HPF CD20-positive cells) and B cell-poor biopsies (<50 CD20-positive cells/HPF) were compared. Serum creatinine and eGFR of B cell-rich (CD20 > 100/HPF) and B cell-poor were not significantly different at rejection, or at 1, 3, 6 and 12 months, and during additional 3 years follow-up after rejection, although higher creatinine at 1 year was noted in the >200/HPF group. Graft survival was also not different between B cell-rich and B cell-poor groups (p = 0.8 for >100/HPF, p = 0.9 for >200/HPF CD20-positive cells). Our data do not support association of B cell-rich infiltrates in allograft biopsies and worse outcome in acute rejection type I or II, but do not exclude the possible contribution of B cells to allograft rejection. |
| | |
Authors:
|
S M Bagnasco; W Tsai; M H Rahman; E S Kraus; L Barisoni; R Vega; L C Racusen; M Haas; B S Mohammed; A A Zachary; R A Montgomery |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons Volume: 7 ISSN: 1600-6135 ISO Abbreviation: Am. J. Transplant. Publication Date: 2007 Aug |
Date Detail:
|
Created Date: 2007-07-09 Completed Date: 2007-09-25 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100968638 Medline TA: Am J Transplant Country: Denmark |
Other Details:
|
Languages: eng Pagination: 1968-73 Citation Subset: IM |
Affiliation:
|
Department of Pathology, Johns Hopkins University, Baltimore, MD, USA. sbagnas1@jhmi.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acute Disease Adult Aged Antigens, CD20 / immunology* B-Lymphocytes / immunology, pathology Creatinine / blood Enzyme-Linked Immunosorbent Assay Female Follow-Up Studies Glomerular Filtration Rate Graft Rejection / blood, immunology, pathology* Graft Survival / immunology* Humans Kidney Transplantation / immunology* Male Middle Aged Prognosis Retrospective Studies Severity of Illness Index Time Factors |
| Chemical | |
Reg. No./Substance:
|
0/Antigens, CD20; 60-27-5/Creatinine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Nephrectomy after transplant failure: current practice and outcomes.
Next Document: Psychological functioning, nonadherence and health outcomes after pediatric liver transplantation.