Document Detail

CD20 expression in B-cell precursor acute lymphoblastic leukemia is common in Mexican patients and lacks a prognostic value.
MedLine Citation:
PMID:  22664043     Owner:  NLM     Status:  In-Data-Review    
Classification of acute lymphoblastic leukemia (ALL) by flow cytometric immunophenotyping characterizes the disease and delineates potential therapeutic intervention. We retrospectively analyzed CD20 expression in 143 patients with newly diagnosed precursor B-cell ALL. CD20 was observed in 61% of patients at diagnosis. There was no correlation between CD20 expression and age, white blood cell count, or cytogenetic abnormalities. Despite the fact that CD20-positive ALL patients had a tendency toward a worse outcome, there was no significant difference between patients with and without CD20 expression in 3-year overall survival 65 vs. 82% (P = 0.14), and cumulative incidence of relapse 36 vs. 18% (P = 0.3) in pediatric patients and 51 vs. 53% (P = 0.31) and 35 vs. 38% (P = 0.6) in adults, respectively. In conclusion, CD20 expression appears to be more common in Mexican patients with newly diagnosed precursor B-cell ALL higher than in Caucasian populations and lacks prognostic value.
Manuel Solano-Genesta; Luz Tarín-Arzaga; Ileana Velasco-Ruiz; Julia A Lutz-Presno; Oscar González-Llano; Consuelo Mancías-Guerra; Laura Rodríguez-Romo; Guillermo J Ruiz-Delgado; Guillermo J Ruiz-Argüelles; José Carlos Jaime-Pérez; David Gómez-Almaguer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hematology (Amsterdam, Netherlands)     Volume:  17     ISSN:  1607-8454     ISO Abbreviation:  Hematology     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-06-05     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9708388     Medline TA:  Hematology     Country:  England    
Other Details:
Languages:  eng     Pagination:  66-70     Citation Subset:  IM    
Hospital Universitario, 'Dr. José E. González' Universidad Autónoma de Nuevo León, Monterrey, NL, Mexico.
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