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CD20 expression in B-cell precursor acute lymphoblastic leukemia is common in Mexican patients and lacks a prognostic value.
MedLine Citation:
PMID:  22664043     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Classification of acute lymphoblastic leukemia (ALL) by flow cytometric immunophenotyping characterizes the disease and delineates potential therapeutic intervention. We retrospectively analyzed CD20 expression in 143 patients with newly diagnosed precursor B-cell ALL. CD20 was observed in 61% of patients at diagnosis. There was no correlation between CD20 expression and age, white blood cell count, or cytogenetic abnormalities. Despite the fact that CD20-positive ALL patients had a tendency toward a worse outcome, there was no significant difference between patients with and without CD20 expression in 3-year overall survival 65 vs. 82% (P = 0.14), and cumulative incidence of relapse 36 vs. 18% (P = 0.3) in pediatric patients and 51 vs. 53% (P = 0.31) and 35 vs. 38% (P = 0.6) in adults, respectively. In conclusion, CD20 expression appears to be more common in Mexican patients with newly diagnosed precursor B-cell ALL higher than in Caucasian populations and lacks prognostic value.
Authors:
Manuel Solano-Genesta; Luz Tarín-Arzaga; Ileana Velasco-Ruiz; Julia A Lutz-Presno; Oscar González-Llano; Consuelo Mancías-Guerra; Laura Rodríguez-Romo; Guillermo J Ruiz-Delgado; Guillermo J Ruiz-Argüelles; José Carlos Jaime-Pérez; David Gómez-Almaguer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hematology (Amsterdam, Netherlands)     Volume:  17     ISSN:  1607-8454     ISO Abbreviation:  Hematology     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-06-05     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9708388     Medline TA:  Hematology     Country:  England    
Other Details:
Languages:  eng     Pagination:  66-70     Citation Subset:  IM    
Affiliation:
Hospital Universitario, 'Dr. José E. González' Universidad Autónoma de Nuevo León, Monterrey, NL, Mexico.
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