| CD20 antigen imaging with <formula>^{124}</formula>I-rituximab PET/CT in patients with rheumatoid arthritis. | |
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MedLine Citation:
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PMID: 21558621 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Introduction: Visualization of the CD20-antigen expression could provide a tool to localize sites of inflammation and could be of additive value in the diagnosis, and subsequently, in the treatment follow-up of patients with rheumatoid arthritis. In this study, an anti-CD20 monoclonal antibody, rituximab (Mabthera®), was radiolabeled with <formula>^{124}</formula>Iodine. We report the first results of <formula>^{124}</formula>I-rituximab PET/CT in patients with rheumatoid arthritis. Methods: Eligible patients received 50 MBq <formula>^{124}</formula>I-rituximab. Wholebody PET/CT imaging was performed at 10 min, 24 h, 48 h and 72-96 h post injection. Images were evaluated primarily on a visual basis and were correlated with disease activity as determined by physical examination and clinical measures. Results: Joints with visually detectable targeting of <formula>^{124}</formula>I-rituximab were observed in 4 out of 5 evaluable patients. Only the images at 24 h and later showed accumulation in joints, indicating that the visualized signal represented active targeting of rituximab to the CD20 antigen. Several images showed CD20 positive B-cell infiltration in joints which were clinically normal, while a few clinically diagnosed arthritis localizations were not visualized. This discrepancy suggests that infiltration of CD20 positive B-cells in synovium is a phenomenon that is at least partially independent of clinical inflammation. The level of uptake in joints was generally low, representing less than 0.5% of the injected dose. Conclusion: We have shown the feasibility of CD20 antigen imaging using <formula>^{124}</formula>I-rituximab in patients with rheumatoid arthritis. Further research is needed to elucidate the clinical significance of demonstrated B-cell infiltration in rheumatic joints. |
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Authors:
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L Tran; A D R Huitema; M H van Rijswijk; H J Dinant; J W Baars; J H Beijnen; W V Vogel |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Human antibodies Volume: 20 ISSN: 1875-869X ISO Abbreviation: Hum Antibodies Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-05-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9711270 Medline TA: Hum Antibodies Country: Netherlands |
Other Details:
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Languages: eng Pagination: 29-35 Citation Subset: IM |
Affiliation:
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Department of Pharmacy & Pharmacology, The Netherlands Cancer Institute / Slotervaart Hospital, Amsterdam, The Netherlands. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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