Document Detail

CD2-mediated regulation of peripheral CD4(+)  CD25(+) regulatory T-cell apoptosis accompanied by down-regulation of Bim.
MedLine Citation:
PMID:  23278598     Owner:  NLM     Status:  MEDLINE    
Extensive studies on CD4(+)  CD25(+) regulatory T (Treg) cells suggest that they are important in regulating immune responses. However, mechanisms of peripheral Treg cell homeostasis are unknown. We found that stromal cells isolated from secondary lymphoid organs such as spleen and lymph nodes could support the survival of Treg cells. This was dependent on CD2 engagement and a direct interaction between Treg cells and stromal cells. In the presence of stromal cells, Bim, a pro-apoptotic factor, was partially decreased in Treg cells. This effect could be inhibited by anti-CD2 blocking antibodies, indicating that stimulation through CD2 on Treg cells regulates Bim expression, which may be relevant to Treg cell apoptosis. Therefore, Treg cell interactions with stromal cells through CD2 may be essential for Treg cell survival. Surprisingly, the expression of CD2 ligands on stromal cells was not detected. Hence, it is not clear how CD2 on Treg cells contributes to a direct interaction with the stromal cells and participates in survival support for Treg cells. Taken together, CD2 stimuli were mandatory for Treg cell survival with reduced Bim expression, but CD2 may not function as a direct receptor for molecules on stromal cells.
Yuji Kashiwakura; Daisuke Sakurai; Yumiko Kanno; Masaaki Hashiguchi; Ayano Kobayashi; Akira Kurosu; Shogo Tokudome; Tetsuji Kobata; Hidefumi Kojima
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Immunology     Volume:  139     ISSN:  1365-2567     ISO Abbreviation:  Immunology     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-04-09     Completed Date:  2013-06-07     Revised Date:  2014-05-07    
Medline Journal Info:
Nlm Unique ID:  0374672     Medline TA:  Immunology     Country:  England    
Other Details:
Languages:  eng     Pagination:  48-60     Citation Subset:  IM    
Copyright Information:
© 2012 Blackwell Publishing Ltd.
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MeSH Terms
Antigens, CD2 / biosynthesis,  genetics,  immunology*
Apoptosis / genetics,  immunology*
Apoptosis Regulatory Proteins / biosynthesis,  genetics,  immunology*
CHO Cells
Cell Communication / genetics,  immunology
Cell Survival
Down-Regulation / genetics,  immunology*
HEK293 Cells
Membrane Proteins / biosynthesis,  genetics,  immunology*
Mice, Inbred BALB C
Proto-Oncogene Proteins / biosynthesis,  genetics,  immunology*
Stromal Cells / cytology,  immunology,  metabolism
T-Lymphocytes, Regulatory / cytology,  immunology*,  metabolism
Reg. No./Substance:
0/Antigens, CD2; 0/Apoptosis Regulatory Proteins; 0/Bcl-2-like protein 11; 0/Membrane Proteins; 0/Proto-Oncogene Proteins

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