Document Detail


CD1a and factor XIIIa immunohistochemistry in leprosy: a possible role of dendritic cells in the pathogenesis of Mycobacterium leprae infection.
MedLine Citation:
PMID:  19590423     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Leprosy is a curable chronic granulomatous infectious disease caused by the bacillus Mycobacterium leprae. This organism has a high affinity for skin and peripheral nerve cells. In the evolution of infections, the immune status of patients determines the disease expression. Dendritic cells are antigen-presenting cells that phagocytose particles and microorganisms. In skin, dendritic cells are represented by epidermal Langerhans cells and dermal dendrocytes, which can be identified by expression of CD1a and factor XIIIa (FXIIIa). In the present study, 29 skin samples from patients with tuberculoid (13 biopsies) and lepromatous (16 biopsies) leprosy were analyzed by immunohistochemistry using antibodies to CD1a and FXIIIa. Quantitative analysis of labeling pattern showed a clear predominance of dendritic cells in tuberculoid leprosy. Difference between the number of positive cells of immunohistochemistry for the CD1a and FXIIIa staining observed in this study indicates a role for dendritic cells in the cutaneous response to leprosy. Dendritic cells may be a determinant of the course and clinical expression of the disease.
Authors:
Juarez Antônio Simões Quaresma; Michell Frank Alves de Oliveira; Angela Cristina Ribeiro Guimarães; Elza Baia de Brito; Rosângela Baia de Brito; Carla Pagliari; Arival Cardoso de Brito; Marília Brasil Xavier; Maria Irma Seixas Duarte
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American Journal of dermatopathology     Volume:  31     ISSN:  1533-0311     ISO Abbreviation:  Am J Dermatopathol     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-07-22     Completed Date:  2009-10-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7911005     Medline TA:  Am J Dermatopathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  527-31     Citation Subset:  IM    
Affiliation:
Laboratório de Imunopatologia, Núcleo de Medicina Tropical, Universidade Federal do Pará, UFPA, Belém-PA, Brazil. juarez@pesquisador.cnpq.br
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MeSH Terms
Descriptor/Qualifier:
Adult
Antigens, CD1 / biosynthesis*
Dendritic Cells / immunology*,  metabolism
Factor XIIIa / biosynthesis*
Female
Humans
Immunohistochemistry
Leprosy / immunology*,  metabolism,  pathology
Male
Chemical
Reg. No./Substance:
0/Antigens, CD1; 0/CD1a antigen; EC 2.3.2.13/Factor XIIIa

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