Document Detail


CD19 expression in acute leukemia is not restricted to the cytogenetically aberrant populations.
MedLine Citation:
PMID:  23193950     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Aberrant expression of the B lymphoid marker, CD19, in acute myeloid leukemia (AML) has frequently been associated with t(8;21)(q22;q22). However, AML cases lacking t(8;21) may occasionally express CD19. We asked whether CD19 expression is restricted to the karyotypically abnormal leukemic cells in primary leukemia samples. We compared, by fluorescence in situ hybridization, CD19-positive and CD19-negative cells from nine patients with acute leukemia: three non-t(8;21) AML, three t(8;21) AML and three cases of acute lymphoblastic leukemia. There were no significant differences in karyotypic pattern between the CD19-positive and CD19-negative leukemic cells, raising the concern that therapeutically targeting CD19 for acute leukemia may not eradicate all malignant clones.
Authors:
Jawad Francis; Avinash V Dharmadhikari; Sheila N J Sait; George Deeb; Paul K Wallace; James E Thompson; Eunice S Wang; Meir Wetzler
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2013-01-03
Journal Detail:
Title:  Leukemia & lymphoma     Volume:  54     ISSN:  1029-2403     ISO Abbreviation:  Leuk. Lymphoma     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-06-19     Completed Date:  2014-02-10     Revised Date:  2014-08-06    
Medline Journal Info:
Nlm Unique ID:  9007422     Medline TA:  Leuk Lymphoma     Country:  England    
Other Details:
Languages:  eng     Pagination:  1517-20     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Antigens, CD19 / genetics,  metabolism*
Chromosome Aberrations*
Gene Expression
Humans
Immunophenotyping
In Situ Hybridization, Fluorescence
Leukemia, Myeloid, Acute / genetics*,  metabolism*
Grant Support
ID/Acronym/Agency:
CA16056/CA/NCI NIH HHS; P30 CA016056/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Antigens, CD19

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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