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CD14CD16 monocyte subset levels in heart failure patients.
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MedLine Citation:
PMID:  20364047     Owner:  NLM     Status:  MEDLINE    
Our aim was to define the distribution of monocyte subsets in a cohort of congestive heart failure (CHF) patients, to verify whether increased severity of CHF is linked to the expansion of specific monocyte subsets, and finally to investigate the relationship between monocyte subset relative frequencies, laboratory parameters of inflammation, and monocyte ACE expression. Thirty consecutive CHF patients and 26 healthy control subjects were evaluated for peripheral blood monocyte expression of CD14, CD16 and CD143 (ACE) by flow-cytometry, and for endothelial-derived soluble CD146 levels by ELISA. CD14++ CD16+ frequency was significantly higher in CHF patients than in Controls (%, median value and IQ) (12.3, 8.7-14.8 vs 5.9, 4.7-6.9, p< 0.05, CHF vs Controls), and it increased depending on how high NYHA class was, on worsening LV ejection fraction and on circulating pro-BNP values. Furthermore, it was associated with increasing creatinine and with decreasing GFR and albumin levels. Monocyte CD143 expression was significantly elevated in CHF patients as compared to Controls, and positively associated with CD14++ CD16+ levels. Frequencies of CD14+ CD16+ monocytes were significantly lower in CHF patients as compared to Controls, and negatively correlated with levels of soluble CD146 (r=-0.529; p 0.048). In conclusion, monocytic CD14++ CD16+ frequency and CD143 levels are increased and reflect disease status and progressive cardiac deterioration in CHF patients. The CD14+ CD16+ subset is depleted in CHF and is linked to endothelial damage in this group of patients. Although the question of whether differences in monocyte CD14CD16 expansion are causal or whether they represent a marker of HF progression which is potentially relevant for risk prediction remains unanswered, we believe that our data represent an important tool for exploring the role of selective inflammatory pathways in CHF progression.
Chiara Barisione; Silvano Garibaldi; Giorgio Ghigliotti; Patrizia Fabbi; Paola Altieri; Maria Carla Casale; Paolo Spallarossa; Giovanni Bertero; Manrico Balbi; Luca Corsiglia; Claudio Brunelli
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Disease markers     Volume:  28     ISSN:  1875-8630     ISO Abbreviation:  Dis. Markers     Publication Date:  2010  
Date Detail:
Created Date:  2010-04-05     Completed Date:  2010-06-29     Revised Date:  2013-12-17    
Medline Journal Info:
Nlm Unique ID:  8604127     Medline TA:  Dis Markers     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  115-24     Citation Subset:  IM    
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MeSH Terms
Antigens, CD14 / blood*
Biological Markers / blood
C-Reactive Protein / metabolism
Case-Control Studies
Cohort Studies
Disease Progression
GPI-Linked Proteins
Heart Failure / blood*,  physiopathology
Inflammation Mediators / blood
Kidney / physiopathology
Leukocyte Count
Monocytes / classification*,  enzymology,  immunology*
Peptidyl-Dipeptidase A / blood
Receptors, IgG / blood*
Reg. No./Substance:
0/Antigens, CD14; 0/Biological Markers; 0/FCGR3B protein, human; 0/GPI-Linked Proteins; 0/Inflammation Mediators; 0/Receptors, IgG; 9007-41-4/C-Reactive Protein; EC A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): Dis Markers
Journal ID (iso-abbrev): Dis. Markers
Journal ID (publisher-id): DM
ISSN: 0278-0240
ISSN: 1875-8630
Publisher: IOS Press
Article Information
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Copyright © 2010 Hindawi Publishing Corporation.
Received Day: 25 Month: 3 Year: 2010
Accepted Day: 25 Month: 3 Year: 2010
Print publication date: Year: 2010
Electronic publication date: Day: 2 Month: 4 Year: 2010
Volume: 28 Issue: 2
First Page: 115 Last Page: 124
PubMed Id: 20364047
ID: 3833331
Article Id: 236405
DOI: 10.3233/DMA-2010-0691

CD14CD16 Monocyte Subset Levels in Heart Failure Patients
Chiara Barisione1
Silvano Garibaldi1
Giorgio Ghigliotti1*
Patrizia Fabbi1
Paola Altieri1
Maria Carla Casale1
Paolo Spallarossa1
Giovanni Bertero1
Manrico Balbi1
Luca Corsiglia2
Claudio Brunelli1
1Division of CardiologyDepartment of Internal MedicineResearch Center of Cardiovascular BiologyUniversity of GenovaV.le Benedetto XV6 16132 GenovaItaly
2Casa Di Cura Istituto Cardiovascolare Camogli (ISC)CamogliItaly
Correspondence: *Giorgio Ghigliotti:

Article Categories:
  • Other

Keywords: Angiotensin, congestive heart failure, monocytes, peptidyl-dipeptidase A, antigens, CD14, receptors, IgG, kidney failure, chronic.

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