Document Detail


CD147 silencing via RNA interference reduces tumor cell invasion, metastasis and increases chemosensitivity in pancreatic cancer cells.
MedLine Citation:
PMID:  22427101     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CD147, which belongs to the immunoglobulin superfamily, is a multifunctional glycoprotein that has been shown to increase tumor invasion, metastasis and multidrug resistance. To define the role of CD147 in invasion and metastasis more precisely, we utilized gene silencing to inhibit the expression of CD147 in pancreatic cancer cells. We observed that CD147 expression was significantly impeded at both the mRNA and protein levels and resulted in a decrease of MMP-2 and MMP-9 activities. There was also a decrease of MCT1 expression in the invasion and metastasis potential of pancreatic cancer cells, as well as increased chemosensitivity to gemcitabine in Panc-1 cells. Overall, these results suggest that CD147 plays an important role in the invasion, metastasis and chemosensitivity of the human pancreatic cancer cell line Panc-1, indicating that CD147 may be a promising therapeutic target for pancreatic cancer.
Authors:
Yuqin Pan; Bangshun He; Guoqi Song; Qian Bao; Zhipeng Tang; Fuliang Tian; Shukui Wang
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-03-15
Journal Detail:
Title:  Oncology reports     Volume:  27     ISSN:  1791-2431     ISO Abbreviation:  Oncol. Rep.     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-04-09     Completed Date:  2012-08-27     Revised Date:  2013-06-03    
Medline Journal Info:
Nlm Unique ID:  9422756     Medline TA:  Oncol Rep     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  2003-9     Citation Subset:  IM    
Affiliation:
Central Laboratory, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu 210006, PR China.
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MeSH Terms
Descriptor/Qualifier:
Antigens, CD147 / genetics,  physiology*
Cell Line, Tumor
Deoxycytidine / analogs & derivatives,  pharmacology
Drug Resistance, Multiple / genetics
Drug Resistance, Neoplasm
Gene Expression Regulation, Neoplastic
Humans
Matrix Metalloproteinase 2 / metabolism*
Matrix Metalloproteinase 9 / metabolism*
Monocarboxylic Acid Transporters / metabolism*
Muscle Proteins / metabolism
Neoplasm Invasiveness
Neoplasm Metastasis
Pancreatic Neoplasms / genetics,  metabolism*,  pathology*
RNA Interference
RNA, Messenger / genetics,  metabolism
RNA, Small Interfering
Symporters / metabolism*
Chemical
Reg. No./Substance:
0/Monocarboxylic Acid Transporters; 0/Muscle Proteins; 0/RNA, Messenger; 0/RNA, Small Interfering; 0/SLC16A4 protein, human; 0/Symporters; 0/monocarboxylate transport protein 1; 136894-56-9/Antigens, CD147; 951-77-9/Deoxycytidine; B76N6SBZ8R/gemcitabine; EC 3.4.24.24/Matrix Metalloproteinase 2; EC 3.4.24.35/Matrix Metalloproteinase 9

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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