Document Detail


CD147, MMP9 expression and clinical significance of basal-like breast cancer.
MedLine Citation:
PMID:  23292863     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Our objective is to investigate the expression of CD147 and metallo-proteinase 9 (MMP9) in patients with basal-like breast cancer (BLBC) so as to determine whether these two genes may be correlated with prognosis of BLBC. We examined the expression of the CD147 and MMP9 in BLBC by immunohistochemistry. Furthermore, we analyzed the correlation between BLBC and several factors related to tumor progression, along with the prognostic value of BLBC. BLBC was significantly associated with CD147 and MMP9 expression (P = 0.000), and prone to lymph node metastasis and distant metastasis. Patients with BLBC showed shorter disease-free survival (P = 0.005) and overall survival (OS) (P = 0.011). In univariate analysis, CD147, MMP9, lymph node metastasis and clinical stage are independent prognostic factors affecting OS. In multivariate analysis, only clinical stage was identified as an independent prognostic factor. Patients with BLBC have a high expression of CD147 and MMP9; BLBC is correlated with a poor prognosis.
Authors:
Ying Liu; Tao Xin; Qiu-Ying Jiang; Da-Yong Huang; Wei-Xi Shen; Li Li; Yan-Ju Lv; Ying-Hua Jin; Xiao-Wei Song; Chong Teng
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Publication Detail:
Type:  Journal Article     Date:  2013-01-06
Journal Detail:
Title:  Medical oncology (Northwood, London, England)     Volume:  30     ISSN:  1559-131X     ISO Abbreviation:  Med. Oncol.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-01-07     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9435512     Medline TA:  Med Oncol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  366     Citation Subset:  IM    
Affiliation:
Department of Oncology, Second Affiliated Hospital of Harbin Medical University, Baojian Road, Harbin, 150086, Heilongjiang, People's Republic of China, yingliu1983@126.com.
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