Document Detail


CD14+ monocyte levels in subgroups of acute coronary syndromes.
MedLine Citation:
PMID:  17925604     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: We aimed to investigate whether there were any differences in the percentages of CD14(+) monocytes between subgroups of acute coronary syndromes (ACS). CD14(+) is a monocyte surface receptor that plays a role in the innate immune system. CD14(+) monocytes are associated with complications of atherosclerosis. METHODS: In total we enrolled 115 patients with ACS: 24 with unstable angina (UA); 29 with non-ST elevation myocardial infarction (NSTEMI); and 62 with ST elevation myocardial infarction (STEMI). The levels of C-reactive protein and percentage of CD14(+) monocyte were measured on admission. RESULTS: CD14(+) monocyte percentages were observed to be different between groups by analysis of variance test. The percentages of CD14(+) monocyte were 81.24+/-10.04% in the UA group; 89.40+/-5.84% in the NSTEMI group; and 87.22+/-11.75% in the STEMI group (P=0.013). The differences between the UA and the NSTEMI and between the UA and the STEMI groups with Bonferroni posthoc testing were significant (P=0.014 and P=0.049 respectively). Moreover, no significant difference was found between the NSTEMI and STEMI groups (P=1.000). The C-reactive protein levels in the UA group were detected to be significantly low with Bonferroni posthoc testing compared with both the NSTEMI and STEMI groups (for both comparisons, P<0.002). CONCLUSIONS: A significant difference in CD14(+) monocyte percentages between subgroups of ACS was determined. CD14(+) monocyte percentages can be a useful parameter in differentiating between the subgroups of ACS, especially between UA and myocardial infarction.
Authors:
Ibrahim Ozdogru; Mehmet Tugrul Inanc; Namk Kemal Eryol; Ali Dogan; Mehmet Gungor Kaya; Ibrahim Gul; Nihat Kalay
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Coronary artery disease     Volume:  18     ISSN:  0954-6928     ISO Abbreviation:  Coron. Artery Dis.     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-10-10     Completed Date:  2008-01-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9011445     Medline TA:  Coron Artery Dis     Country:  England    
Other Details:
Languages:  eng     Pagination:  519-22     Citation Subset:  IM    
Affiliation:
Department of Cardiology, Erciyes University School of Medicine, Kayseri, Turkey. iozdogru@erciyes.edu.tr
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MeSH Terms
Descriptor/Qualifier:
Acute Coronary Syndrome / blood*,  metabolism*
Aged
Antigens, CD14 / biosynthesis*
Atherosclerosis / complications
C-Reactive Protein / biosynthesis
Cardiology / methods
Female
Flow Cytometry
Humans
Male
Middle Aged
Models, Biological
Monocytes / metabolism
Myocardial Infarction / blood*,  metabolism
Treatment Outcome
Chemical
Reg. No./Substance:
0/Antigens, CD14; 9007-41-4/C-Reactive Protein

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