| CD14+ monocyte levels in subgroups of acute coronary syndromes. | |
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MedLine Citation:
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PMID: 17925604 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: We aimed to investigate whether there were any differences in the percentages of CD14(+) monocytes between subgroups of acute coronary syndromes (ACS). CD14(+) is a monocyte surface receptor that plays a role in the innate immune system. CD14(+) monocytes are associated with complications of atherosclerosis. METHODS: In total we enrolled 115 patients with ACS: 24 with unstable angina (UA); 29 with non-ST elevation myocardial infarction (NSTEMI); and 62 with ST elevation myocardial infarction (STEMI). The levels of C-reactive protein and percentage of CD14(+) monocyte were measured on admission. RESULTS: CD14(+) monocyte percentages were observed to be different between groups by analysis of variance test. The percentages of CD14(+) monocyte were 81.24+/-10.04% in the UA group; 89.40+/-5.84% in the NSTEMI group; and 87.22+/-11.75% in the STEMI group (P=0.013). The differences between the UA and the NSTEMI and between the UA and the STEMI groups with Bonferroni posthoc testing were significant (P=0.014 and P=0.049 respectively). Moreover, no significant difference was found between the NSTEMI and STEMI groups (P=1.000). The C-reactive protein levels in the UA group were detected to be significantly low with Bonferroni posthoc testing compared with both the NSTEMI and STEMI groups (for both comparisons, P<0.002). CONCLUSIONS: A significant difference in CD14(+) monocyte percentages between subgroups of ACS was determined. CD14(+) monocyte percentages can be a useful parameter in differentiating between the subgroups of ACS, especially between UA and myocardial infarction. |
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Authors:
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Ibrahim Ozdogru; Mehmet Tugrul Inanc; Namk Kemal Eryol; Ali Dogan; Mehmet Gungor Kaya; Ibrahim Gul; Nihat Kalay |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Coronary artery disease Volume: 18 ISSN: 0954-6928 ISO Abbreviation: Coron. Artery Dis. Publication Date: 2007 Nov |
Date Detail:
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Created Date: 2007-10-10 Completed Date: 2008-01-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9011445 Medline TA: Coron Artery Dis Country: England |
Other Details:
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Languages: eng Pagination: 519-22 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Erciyes University School of Medicine, Kayseri, Turkey. iozdogru@erciyes.edu.tr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Coronary Syndrome
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blood*,
metabolism* Aged Antigens, CD14 / biosynthesis* Atherosclerosis / complications C-Reactive Protein / biosynthesis Cardiology / methods Female Flow Cytometry Humans Male Middle Aged Models, Biological Monocytes / metabolism Myocardial Infarction / blood*, metabolism Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD14; 9007-41-4/C-Reactive Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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