| CD14 gene -260 C/T polymorphism is associated with chronic heart failure. | |
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MedLine Citation:
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PMID: 16137548 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Patients with chronic heart failure (CHF) show inflammatory changes and elevated plasma levels of TNFalpha and endotoxins. However, the role of the CD14 C(-260)T polymorphism in patients with CHF is unclear. Therefore, we sought to determine whether the C=>T promoter polymorphism (position -260) of the CD 14 gene is associated with a higher risk for the development of CHF. METHODS: We studied 100 patients with CHF (mean age 62+/-3 years, LVEF 28+/-8%) and 100 healthy controls (59+/-10 years, p=NS; LVEF 60+/-4%, p<0.05). CD14 genotyping was performed using a PCR-RFLP technique. RESULTS: Among CHF patients, the frequency of the T allele was lower (38% vs. 48%, p<0.05) and the frequency of the C allele higher (62 % vs. 52 %, p<0.05) than among controls. The distribution of CD14 genotypes in healthy controls was as follows: CC 32%, CT 40%, and TT 28%. Among CHF patients, the TT genotype was significantly underrepresented compared to controls: CC 38%, CT 48%, and TT 14% (p<0.05). CONCLUSIONS: The C -260T polymorphism of CD14 seems to influence the susceptibility for the development of CHF. The T allele is less frequent among CHF patients than among controls. The TT genotype could be a new genetic protective factor against the development of CHF. |
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Authors:
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Stefan Krüger; Jürgen Graf; Marc W Merx; Tina Stickel; Karl Christian Koch; Uwe Janssens; Peter Hanrath; Dagmar Kunz |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European journal of internal medicine Volume: 16 ISSN: 0953-6205 ISO Abbreviation: Eur. J. Intern. Med. Publication Date: 2005 Sep |
Date Detail:
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Created Date: 2005-09-02 Completed Date: 2005-10-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9003220 Medline TA: Eur J Intern Med Country: Netherlands |
Other Details:
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Languages: eng Pagination: 345-7 Citation Subset: - |
Affiliation:
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Medizinische Klinik I, Universitätsklinikum, Rheinisch Westfälische Technische Hochschule, Pauwelsstrasse 30, 52057 Aachen, Germany. skrueger@lukasneuss.de |
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