| CD14 expression and Kupffer cell dysfunction in nonalcoholic steatohepatitis: SPIO-MRI and pathologic correlation. | |
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MedLine Citation:
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PMID: 22188204 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background and Aim: Kupffer cell (KC) function and CD14 expression contributes to pathogenesis of nonalcoholic steatohepatitis (NASH). However, these relationships remain unclear. We investigated the relationship of KC function with superparamagnetic iron oxide-enhanced magnetic resonance imaging (SPIO-MRI), histopathological severity of NASH, and number of CD14-positive KCs in NASH. Methods: This retrospective study included 32 patients (24 with NASH and eight with simple steatosis) who had previously undergone SPIO-MRI with T2-weighted gradient-recalled echo sequence. All subjects were diagnosed pathologically and were evaluated for necroinflammation grade, fibrosis stage, and number of CD14-positive KCs. Patients with NASH and simple steatosis were compared by using the Mann-Whitney test to determine differences in percent reduction of liver-to-muscle signal intensity ratio (reduction-%LMR), as a surrogate parameter of KC function, and number of CD14-positive KCs. Kruskal-Wallis test and Pearson correlation coefficient were used to analyze relation among reduction-%LMR, histopathological severity and number of CD14-positive KCs. Results: There were statistically significant differences in reduction-%LMR and number of CD14-positive KCs between NASH and simple steatosis patients (Mann-Whitney test, P < 0.001 for all comparisons). Reduction-%LMR decreased with an increase in necroinflammation grade or fibrosis stage. The number of CD14-positive KCs increased with an increase in necroinflammation grade and fibrosis stage (Kruskal-Wallis test, both, P < 0.001). A high correlation was seen between number of CD14-positive KCs and reduction-%LMR (Pearson r= 0.81; P < 0.001). Conclusions: KC phagocytic function evaluated with SPIO-MRI correlated with histopathological severity and number of CD14-positive KCs. These results support the concept that KC phagocytic dysfunction contributes to the pathogenesis of NASH. |
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Authors:
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Tatsuyuki Tonan; Kiminori Fujimoto; Aliya Qayyum; Yasuyo Morita; Osamu Nakashima; Noriyuki Ono; Akihiko Kawahara; Masayoshi Kage; Naofumi Hayabuchi; Takato Ueno |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-21 |
Journal Detail:
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Title: Journal of gastroenterology and hepatology Volume: - ISSN: 1440-1746 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8607909 Medline TA: J Gastroenterol Hepatol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2011 Journal of Gastroenterology and Hepatology Foundation and Blackwell Publishing Asia Pty Ltd. |
Affiliation:
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Department of Radiology, Kurume University School of Medicine and Center for Diagnostic Imaging, Kurume University Hospital, 67 Asahi-machi, Kurume, 830-0011, Japan Department of Radiology and Biomedical Imaging, University of California San Francisco, 505 Parnassus Ave, Room L-307, Box 0628, San Francisco, CA94143, USA Department of Internal Medicine, Nagata Hospital, 523-1 Shimomiyanaga-machi, Yanagawa, 832-0059, Japan Department of Clinical Inspection, Kurume University Hospital, 67 Asahi-machi, Kurume, 830-0011, Japan. Department of Internal Medicine, Chikugo City Hospital, 917-1 Izumi, Chikugo, 833-0041, Japan Department of Diagnostic Pathology, Kurume University School of Medicine, 67 Asahi-machi, Kurume, 830-0011, Japan. Research Center for Innovative Cancer Therapy, Kurume University School of Medicine, 67 Asahi-machi, Kurume, 830-0011, Japan. |
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