Document Detail


CD14 (C-260T) polymorphism is not associated with sudden infant death syndrome (SIDS) in a large South Australian cohort.
MedLine Citation:
PMID:  20472613     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Similarities have been drawn between models of endotoxic shock and gross and microscopic pathology observed in sudden infant death syndrome (SIDS) cases. Polymorphisms in genes that influence the expression of endotoxin receptors could affect the outcome of toxaemia, and could, therefore, play a role in SIDS. The CD14 gene promoter contains a single nucleotide polymorphism that affects the level of CD14 gene expression. The TT genotype of the CD14 (C-260T) polymorphism causes a significantly higher density of CD14 receptor expression on monocytes which makes the individual more sensitive to endotoxin than those with the wild-type (CC). This investigation was designed to determine whether SIDS infants have a higher frequency of the CD14 (C-260T) polymorphism compared with non-SIDS controls. One hundred and sixteen SIDS and 228 control infants were genotyped using PCR followed by restriction fragment length analysis of amplified product. Carriage of the TT or CT genotypes did not significantly differ between SIDS and control infants (P = 0.218 and 0.081, respectively). The frequencies observed in the control group were consistent with Hardy-Weinberg equilibrium and did not differ significantly from the published frequencies in Caucasian Australians. These results suggest that CD14 (C-260T) polymorphism is unlikely to be implicated in SIDS.
Authors:
Amanda R Highet; Catherine S Gibson; Paul N Goldwater
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-05-14
Journal Detail:
Title:  Innate immunity     Volume:  17     ISSN:  1753-4267     ISO Abbreviation:  Innate Immun     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-06-06     Completed Date:  2011-10-21     Revised Date:  2012-02-22    
Medline Journal Info:
Nlm Unique ID:  101469670     Medline TA:  Innate Immun     Country:  United States    
Other Details:
Languages:  eng     Pagination:  321-6     Citation Subset:  IM    
Affiliation:
Department of Microbiology and Infectious Diseases, SA Pathology at the Women's & Children's Hospital, North Adelaide, SA 5005, Australia. amanda.highet@adelaide.edu.au
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MeSH Terms
Descriptor/Qualifier:
Antigens, CD14 / genetics,  metabolism*
Australia
Cohort Studies
Female
Gene Frequency
Genetic Association Studies
Genetic Predisposition to Disease
Genotype
Humans
Infant, Newborn
Male
Mutation / genetics
Polymorphism, Single Nucleotide
Population Groups*
Sudden Infant Death / epidemiology,  genetics*,  immunology
Chemical
Reg. No./Substance:
0/Antigens, CD14

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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