Document Detail


CD103+ GALT DCs promote Foxp3+ regulatory T cells.
MedLine Citation:
PMID:  19079226     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
There is evidence that Foxp3(+) regulatory T (T(R)) cells contribute to intestinal homeostasis and that deficiencies in this population can lead to chronic intestinal inflammation. Here, we review recent studies that demonstrate that the gut is a site of peripheral generation of T(R) cells. Functionally specialized gut dendritic cell populations promote T(R) cells through a transforming growth factor-beta and retinoic acid-dependent mechanism. Gut-driven T(R) cells may represent a tissue-specific mechanism to broaden the repertoire of T(R) cells focussed on the gut.
Authors:
K R R Siddiqui; F Powrie
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Mucosal immunology     Volume:  1 Suppl 1     ISSN:  1935-3456     ISO Abbreviation:  -     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-12-16     Completed Date:  2009-02-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101299742     Medline TA:  Mucosal Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S34-8     Citation Subset:  IM    
Affiliation:
Sir William Dunn School of Pathology, University of Oxford, Oxford, UK.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antigens, CD / immunology*
Dendritic Cells / immunology*
Forkhead Transcription Factors / immunology*
Humans
Integrin alpha Chains / immunology*
Intestines / immunology*
Lymphoid Tissue / immunology*
T-Lymphocytes, Regulatory / immunology*
Grant Support
ID/Acronym/Agency:
//Medical Research Council; //Wellcome Trust
Chemical
Reg. No./Substance:
0/Antigens, CD; 0/Forkhead Transcription Factors; 0/Integrin alpha Chains; 0/alpha E integrins

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