| The CD100 receptor interacts with its plexin B2 ligand to regulate epidermal γδ T cell function. | |
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MedLine Citation:
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PMID: 22902232 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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γδ T cells respond rapidly to keratinocyte damage, providing essential contributions to the skin wound healing process. The molecular interactions regulating their response are unknown. Here, we identify a role for interaction of plexin B2 with the CD100 receptor in epithelial repair. In vitro blocking of plexin B2 or CD100 inhibited γδ T cell activation. Furthermore, CD100 deficiency in vivo resulted in delayed repair of cutaneous wounds due to a disrupted γδ T cell response to keratinocyte damage. Ligation of CD100 in γδ T cells induced cellular rounding via signals through ERK kinase and cofilin. Defects in this rounding process were evident in the absence of CD100-mediated signals, thereby providing a mechanistic explanation for the defective wound healing in CD100-deficient animals. The discovery of immune functions for plexin B2 and CD100 provides insight into the complex cell-cell interactions between epithelial resident γδ T cells and the neighboring cells they support. |
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Authors:
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Deborah A Witherden; Megumi Watanabe; Olivia Garijo; Stephanie E Rieder; Gor Sarkisyan; Shane J F Cronin; Petra Verdino; Ian A Wilson; Atsushi Kumanogoh; Hitoshi Kikutani; Luc Teyton; Wolfgang H Fischer; Wendy L Havran |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2012-08-16 |
Journal Detail:
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Title: Immunity Volume: 37 ISSN: 1097-4180 ISO Abbreviation: Immunity Publication Date: 2012 Aug |
Date Detail:
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Created Date: 2012-08-27 Completed Date: 2012-11-19 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 9432918 Medline TA: Immunity Country: United States |
Other Details:
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Languages: eng Pagination: 314-25 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Actin Depolymerizing Factors
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metabolism Animals Antigens, CD / immunology*, metabolism CHO Cells Cell Communication / immunology Cell Shape Cricetinae Epidermis / immunology, injuries Extracellular Signal-Regulated MAP Kinases / metabolism HEK293 Cells Humans Keratinocytes / immunology, metabolism Langerhans Cells / immunology*, metabolism Lymphocyte Activation / immunology Mass Spectrometry Mice Mice, Inbred C57BL Mice, Transgenic Nerve Tissue Proteins / immunology*, metabolism Phosphorylation Protein Binding / immunology Receptors, Antigen, T-Cell, gamma-delta / immunology*, metabolism Semaphorins / immunology*, metabolism Sequence Analysis, Protein Surface Plasmon Resonance T-Lymphocytes / immunology*, metabolism Wound Healing / immunology |
| Grant Support | |
ID/Acronym/Agency:
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AI32751/AI/NIAID NIH HHS; AI36964/AI/NIAID NIH HHS; AI42266/AI/NIAID NIH HHS; AI52257/AI/NIAID NIH HHS; CA58896/CA/NCI NIH HHS; NS057096/NS/NINDS NIH HHS; R01 AI032751/AI/NIAID NIH HHS; R01 AI036964/AI/NIAID NIH HHS; R01 AI042266/AI/NIAID NIH HHS; R01 AI052257/AI/NIAID NIH HHS; R01 CA058896/CA/NCI NIH HHS; RR022988/RR/NCRR NIH HHS; S10 RR022988/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Actin Depolymerizing Factors; 0/Antigens, CD; 0/CD100 antigen; 0/Nerve Tissue Proteins; 0/Receptors, Antigen, T-Cell, gamma-delta; 0/Semaphorins; 0/plexin B2 protein, mouse; EC 2.7.11.24/Extracellular Signal-Regulated MAP Kinases |
| Comments/Corrections | |
Comment In:
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Immunity. 2012 Aug 24;37(2):194-6
[PMID:
22921116
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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