Document Detail


The CD100 receptor interacts with its plexin B2 ligand to regulate epidermal γδ T cell function.
MedLine Citation:
PMID:  22902232     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
γδ T cells respond rapidly to keratinocyte damage, providing essential contributions to the skin wound healing process. The molecular interactions regulating their response are unknown. Here, we identify a role for interaction of plexin B2 with the CD100 receptor in epithelial repair. In vitro blocking of plexin B2 or CD100 inhibited γδ T cell activation. Furthermore, CD100 deficiency in vivo resulted in delayed repair of cutaneous wounds due to a disrupted γδ T cell response to keratinocyte damage. Ligation of CD100 in γδ T cells induced cellular rounding via signals through ERK kinase and cofilin. Defects in this rounding process were evident in the absence of CD100-mediated signals, thereby providing a mechanistic explanation for the defective wound healing in CD100-deficient animals. The discovery of immune functions for plexin B2 and CD100 provides insight into the complex cell-cell interactions between epithelial resident γδ T cells and the neighboring cells they support.
Authors:
Deborah A Witherden; Megumi Watanabe; Olivia Garijo; Stephanie E Rieder; Gor Sarkisyan; Shane J F Cronin; Petra Verdino; Ian A Wilson; Atsushi Kumanogoh; Hitoshi Kikutani; Luc Teyton; Wolfgang H Fischer; Wendy L Havran
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-08-16
Journal Detail:
Title:  Immunity     Volume:  37     ISSN:  1097-4180     ISO Abbreviation:  Immunity     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-08-27     Completed Date:  2012-11-19     Revised Date:  2013-08-27    
Medline Journal Info:
Nlm Unique ID:  9432918     Medline TA:  Immunity     Country:  United States    
Other Details:
Languages:  eng     Pagination:  314-25     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Affiliation:
Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
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MeSH Terms
Descriptor/Qualifier:
Actin Depolymerizing Factors / metabolism
Animals
Antigens, CD / immunology*,  metabolism
CHO Cells
Cell Communication / immunology
Cell Shape
Cricetinae
Epidermis / immunology,  injuries
Extracellular Signal-Regulated MAP Kinases / metabolism
HEK293 Cells
Humans
Keratinocytes / immunology,  metabolism
Langerhans Cells / immunology*,  metabolism
Lymphocyte Activation / immunology
Mass Spectrometry
Mice
Mice, Inbred C57BL
Mice, Transgenic
Nerve Tissue Proteins / immunology*,  metabolism
Phosphorylation
Protein Binding / immunology
Receptors, Antigen, T-Cell, gamma-delta / immunology*,  metabolism
Semaphorins / immunology*,  metabolism
Sequence Analysis, Protein
Surface Plasmon Resonance
T-Lymphocytes / immunology*,  metabolism
Wound Healing / immunology
Grant Support
ID/Acronym/Agency:
AI32751/AI/NIAID NIH HHS; AI36964/AI/NIAID NIH HHS; AI42266/AI/NIAID NIH HHS; AI52257/AI/NIAID NIH HHS; CA58896/CA/NCI NIH HHS; NS057096/NS/NINDS NIH HHS; P30 NS057096/NS/NINDS NIH HHS; R01 AI032751/AI/NIAID NIH HHS; R01 AI036964/AI/NIAID NIH HHS; R01 AI042266/AI/NIAID NIH HHS; R01 AI052257/AI/NIAID NIH HHS; R01 CA058896/CA/NCI NIH HHS; RR022988/RR/NCRR NIH HHS; S10 RR022988/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Actin Depolymerizing Factors; 0/Antigens, CD; 0/CD100 antigen; 0/Nerve Tissue Proteins; 0/Receptors, Antigen, T-Cell, gamma-delta; 0/Semaphorins; 0/plexin B2 protein, mouse; EC 2.7.11.24/Extracellular Signal-Regulated MAP Kinases
Comments/Corrections
Comment In:
Immunity. 2012 Aug 24;37(2):194-6   [PMID:  22921116 ]

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