| APC/C-CCS52A complexes control meristem maintenance in the Arabidopsis root. | |
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MedLine Citation:
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PMID: 19553203 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Plant organs originate from meristems where stem cells are maintained to produce continuously daughter cells that are the source of different cell types. The cell cycle switch gene CCS52A, a substrate specific activator of the anaphase promoting complex/cyclosome (APC/C), controls the mitotic arrest and the transition of mitotic cycles to endoreduplication (ER) cycles as part of cell differentiation. Arabidopsis, unlike other organisms, contains 2 CCS52A isoforms. Here, we show that both of them are active and regulate meristem maintenance in the root tip, although through different mechanisms. The CCS52A1 activity in the elongation zone of the root stimulates ER and mitotic exit, and contributes to the border delineation between dividing and expanding cells. In contrast, CCS52A2 acts directly in the distal region of the root meristem to control identity of the quiescent center (QC) cells and stem cell maintenance. Cell proliferation assays in roots suggest that this control involves CCS52A2 mediated repression of mitotic activity in the QC cells. The data indicate that the CCS52A genes favor a low mitotic state in different cell types of the root tip that is required for meristem maintenance, and reveal a previously undescribed mechanism for APC/C mediated control in plant development. |
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Authors:
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Marleen Vanstraelen; Mikhail Baloban; Olivier Da Ines; Antonietta Cultrone; Tim Lammens; Véronique Boudolf; Spencer C Brown; Lieven De Veylder; Peter Mergaert; Eva Kondorosi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-06-24 |
Journal Detail:
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Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 106 ISSN: 1091-6490 ISO Abbreviation: Proc. Natl. Acad. Sci. U.S.A. Publication Date: 2009 Jul |
Date Detail:
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Created Date: 2009-07-20 Completed Date: 2009-09-09 Revised Date: 2010-09-27 |
Medline Journal Info:
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Nlm Unique ID: 7505876 Medline TA: Proc Natl Acad Sci U S A Country: United States |
Other Details:
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Languages: eng Pagination: 11806-11 Citation Subset: IM |
Affiliation:
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Institut des Sciences du Végétal, Centre National de la Recherche Scientifique, Unité Propre de Recherche 2355, 91198 Gif-sur-Yvette cedex, France. |
| Data Bank Information | |
Bank Name/Acc. No.:
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RefSeq/NM_117262; NM_118420 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Arabidopsis
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genetics,
physiology* Arabidopsis Proteins / genetics, metabolism* Cell Cycle Proteins / genetics, metabolism* Cell Proliferation Flow Cytometry Genetic Vectors / genetics In Situ Hybridization Meristem / genetics, physiology* Mitosis / physiology* Plant Roots / genetics, physiology* Protein Isoforms / genetics, metabolism Reverse Transcriptase Polymerase Chain Reaction Ubiquitin-Protein Ligase Complexes / genetics, metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Arabidopsis Proteins; 0/Cell Cycle Proteins; 0/FZR2 protein, Arabidopsis; 0/Protein Isoforms; EC 6.3.2.19/Ubiquitin-Protein Ligase Complexes; EC 6.3.2.19/anaphase-promoting complex |
| Comments/Corrections | |
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