| CCR7 is expressed in astrocytes and upregulated after an inflammatory injury. | |
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MedLine Citation:
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PMID: 20638137 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Neurodegenerative or autoimmune diseases are frequently regulated by chemokines and their receptors, controlling both glial activation and immune cell infiltration. CCL19 and CCL21 have been described to mediate crucial functions during CNS pathological states, regulating both immune cell traffic to the CNS and communication between glia and neurons. Here, we describe the expression pattern and cellular sources of CCR7, receptor of CCL19 and CCL21, in the normal mouse brain. Moreover, we found that CCR7 is upregulated in reactive astrocytes upon intracerebral LPS, regulating early glial reactivity through its ligands CCL19 and CCL21. Our results indicate that CCR7 is playing an important role for the intercellular communication during the inflammatory activation in the CNS. |
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Authors:
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Diego Gomez-Nicola; Noemí Pallas-Bazarra; Beatriz Valle-Argos; Manuel Nieto-Sampedro |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2010-07-16 |
Journal Detail:
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Title: Journal of neuroimmunology Volume: 227 ISSN: 1872-8421 ISO Abbreviation: J. Neuroimmunol. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-20 Completed Date: 2010-10-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8109498 Medline TA: J Neuroimmunol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 87-92 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier B.V. All rights reserved. |
Affiliation:
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Neural Plasticity Group, Functional and Systems Neurobiology Department, Cajal Institute, CSIC, Avda Doctor Arce, 37, 28002, Madrid, Spain. dgomez@cajal.csic.es |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Astrocytes / metabolism*, pathology* Cell Communication / genetics, immunology Cells, Cultured Inflammation Mediators / metabolism, physiology* Lipopolysaccharides / administration & dosage, toxicity* Male Mice Mice, Inbred C57BL Microglia / immunology, metabolism, pathology Neurogenesis / genetics, immunology Receptors, CCR7 / biosynthesis*, genetics*, physiology Up-Regulation / immunology* |
| Chemical | |
Reg. No./Substance:
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0/Ccr7 protein, mouse; 0/Inflammation Mediators; 0/Lipopolysaccharides; 0/Receptors, CCR7 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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