Document Detail


CCR6hiCD11c(int) B cells promote M-cell differentiation in Peyer's patch.
MedLine Citation:
PMID:  21422150     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
M cells are responsible for uptake of mucosal antigens in Peyer's patches (PPs). Differentiation of M cells is thought to be induced by interactions between follicle-associated epithelium and PP cells; however, it remains elusive what types of immune cells function as M-cell inducers. Here, we attempted to identify the cells that serve as an M-cell inducer in PP. We found that a unique B-cell subset characterized by CCR6(hi)CD11c(int) resided in the subepithelial dome (SED) in mouse PP. CCR6(hi)CD11c(int) B cells showed chemotactic migration in response to CCL20. Furthermore, this unique B-cell subset substantially decreased in PP of CCR6-deficient mice, indicating that the SED localization of CCR6(hi)CD11c(int) B cells is most likely regulated by the CCL20-CCR6 system. Concomitantly, CCR6 deficiency caused remarkable decrement of M cells. Moreover, adoptive transfer of CCR6(hi)CD11c(int) B cells from wild-type mice restored the M-cell decrement in CCR6-deficient mice. Collectively, the spatial regulation of CCR6(hi)CD11c(int) B cells via the CCL20-CCR6 system may play a vital role in M-cell differentiation in mice.
Authors:
Masashi Ebisawa; Koji Hase; Daisuke Takahashi; Hiroshi Kitamura; Kathryn A Knoop; Ifor R Williams; Hiroshi Ohno
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-03-21
Journal Detail:
Title:  International immunology     Volume:  23     ISSN:  1460-2377     ISO Abbreviation:  Int. Immunol.     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-03-30     Completed Date:  2011-07-18     Revised Date:  2014-09-14    
Medline Journal Info:
Nlm Unique ID:  8916182     Medline TA:  Int Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  261-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adoptive Transfer
Animals
Antigens, CD11c / biosynthesis
B-Lymphocytes / cytology,  immunology,  metabolism*
Cell Differentiation
Cell Movement / genetics
Cells, Cultured
Chemokine CCL20 / metabolism
Epithelial Cells / cytology,  immunology,  metabolism*
Lymphocyte Subsets / cytology,  immunology,  metabolism*
Mice
Mice, Inbred C57BL
Mice, Knockout
Peyer's Patches / cytology*
Receptors, CCR6 / genetics,  immunology,  metabolism*
Grant Support
ID/Acronym/Agency:
R01 DK064730/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Antigens, CD11c; 0/CCR6 protein, human; 0/Chemokine CCL20; 0/Receptors, CCR6
Comments/Corrections

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