| CCR6hiCD11c(int) B cells promote M-cell differentiation in Peyer's patch. | |
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MedLine Citation:
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PMID: 21422150 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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M cells are responsible for uptake of mucosal antigens in Peyer's patches (PPs). Differentiation of M cells is thought to be induced by interactions between follicle-associated epithelium and PP cells; however, it remains elusive what types of immune cells function as M-cell inducers. Here, we attempted to identify the cells that serve as an M-cell inducer in PP. We found that a unique B-cell subset characterized by CCR6(hi)CD11c(int) resided in the subepithelial dome (SED) in mouse PP. CCR6(hi)CD11c(int) B cells showed chemotactic migration in response to CCL20. Furthermore, this unique B-cell subset substantially decreased in PP of CCR6-deficient mice, indicating that the SED localization of CCR6(hi)CD11c(int) B cells is most likely regulated by the CCL20-CCR6 system. Concomitantly, CCR6 deficiency caused remarkable decrement of M cells. Moreover, adoptive transfer of CCR6(hi)CD11c(int) B cells from wild-type mice restored the M-cell decrement in CCR6-deficient mice. Collectively, the spatial regulation of CCR6(hi)CD11c(int) B cells via the CCL20-CCR6 system may play a vital role in M-cell differentiation in mice. |
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Authors:
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Masashi Ebisawa; Koji Hase; Daisuke Takahashi; Hiroshi Kitamura; Kathryn A Knoop; Ifor R Williams; Hiroshi Ohno |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2011-03-21 |
Journal Detail:
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Title: International immunology Volume: 23 ISSN: 1460-2377 ISO Abbreviation: Int. Immunol. Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-03-30 Completed Date: 2011-07-18 Revised Date: 2012-10-09 |
Medline Journal Info:
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Nlm Unique ID: 8916182 Medline TA: Int Immunol Country: England |
Other Details:
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Languages: eng Pagination: 261-9 Citation Subset: IM |
Affiliation:
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Laboratory for Epithelial Immunobiology, Research Center for Allergy and Immunology, RIKEN, Yokohama, Kanagawa 230-0045, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adoptive Transfer Animals Antigens, CD11c / biosynthesis B-Lymphocytes / cytology, immunology, metabolism* Cell Differentiation Cell Movement / genetics Cells, Cultured Chemokine CCL20 / metabolism Epithelial Cells / cytology, immunology, metabolism* Lymphocyte Subsets / cytology, immunology, metabolism* Mice Mice, Inbred C57BL Mice, Knockout Peyer's Patches / cytology* Receptors, CCR6 / genetics, immunology, metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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R01 DK064730/DK/NIDDK NIH HHS; R01 DK064730-07/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD11c; 0/CCR6 protein, human; 0/Chemokine CCL20; 0/Receptors, CCR6 |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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