Document Detail


CCR5 promoter polymorphisms and HIV-1 perinatal transmission in Brazilian children.
MedLine Citation:
PMID:  16233918     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The frequencies of four CCR5 promoter polymorphisms, and of the Delta32 deletion, have been evaluated in Brazilian HIV-1 positive (HIV+) and HIV-1 negative (HIV-) children, both born from HIV-1 positive mothers and healthy controls (HC), with the aim of investigating whether CCR5 polymorphisms could be associated to vertical transmission of HIV-1. One hundred and six HIV-1 positive children and 70 HIV-1 negative children were enrolled from impoverished areas of Recife (Brazil). We recruited also as healthy controls 104 uninfected children from the same ethnic background, matched for age and known to be not at risk for HIV-1 infection. CCR5 polymorphisms were detected by PCR amplification and direct sequencing. Although no significative divergence was found for CCR5 Delta32, CCR5-59356-C/T and CCR5-59653 C/T polymorphisms, the frequency of CCR5-59353-T/C and CCR5-59402-A/G genotypes differed among HIV+, HIV- and HC children. The presence of the CCR5-59353-TT genotype indicated a trend for increased risk of vertical transmission of HIV-1 infection in Brazilian children, while the presence of the CCR5-59402-AA genotype is suggestive for a protective effect against HIV-1 vertical transmission.
Authors:
P R de Souza; L C Arraes; J L de Lima Filho; D Bruneska; M Milanese; S Crovella
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-10-17
Journal Detail:
Title:  Journal of reproductive immunology     Volume:  69     ISSN:  0165-0378     ISO Abbreviation:  J. Reprod. Immunol.     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-01-30     Completed Date:  2006-04-03     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8001906     Medline TA:  J Reprod Immunol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  77-84     Citation Subset:  IM    
Affiliation:
LIKA, Universidade Federal de Pernambuco, Recife, Brazil.
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MeSH Terms
Descriptor/Qualifier:
Brazil
Child
Child, Preschool
Female
Gene Frequency
HIV Infections / epidemiology,  genetics*,  transmission*
HIV-1*
Humans
Infectious Disease Transmission, Vertical*
Male
Polymorphism, Genetic*
Pregnancy
Promoter Regions, Genetic / genetics
Receptors, CCR5 / genetics*
Chemical
Reg. No./Substance:
0/Receptors, CCR5

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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