| CCR5 promoter polymorphisms, CCR5 59029A and CCR5 59353C, are under represented in HIV-1-infected long-term non-progressors. The Australian Long-Term Non-Progressor Study Group. | |
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MedLine Citation:
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PMID: 10708279 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine the influence of CCR5 promoter polymorphisms on HIV-1 progression to AIDS and to evaluate the interaction between CCR5 structural polymorphisms and those occurring in the regulatory region of the same gene. PARTICIPANTS: Seventy-one HIV-1-infected long-term non-progressors with a CD4+ T cell count of > 500 x 10(6)/I more than 8 years after infection were compared with 75 HIV-1-infected individuals who had progressed to AIDS and/or death within 8 years and with a further 119 HIV-1-positive patients who had CD4+ T cell counts of 200-500 x 10(6)/l. An additional 92 HIV-negative individuals were also studied. METHODS: CCR5 delta32 genotype was determined by PCR with primers spanning the 32 base pair deletion. CCR2-64I, CCR5 59029A/G and CCR5 59353C/T genotypes were determined by PCR followed by restriction fragment length polymorphism analysis. RESULTS: Strong linkage disequilibrium between the CCR5 59029A and CCR5 59353C polymorphic variants was identified. CCR5 59029A and CCR5 59353C homozygotes were found to be significantly under-represented in the long-term non-progressor group as compared with the other HIV-1-positive groups, with the effect being more marked in the absence of the CCR5 delta32 and CCR2 64I mutations. CONCLUSIONS: This study provides the first evidence for an association between CCR5 promoter polymorphisms and long-term asymptomatic HIV-1 infection, with individuals lacking the CCR5 59029A/CCR5 59353C homozygous genotype likely to progress more slowly towards AIDS and/or death. |
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Authors:
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A O Clegg; L J Ashton; R A Biti; P Badhwar; P Williamson; J M Kaldor; G J Stewart |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: AIDS (London, England) Volume: 14 ISSN: 0269-9370 ISO Abbreviation: AIDS Publication Date: 2000 Jan |
Date Detail:
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Created Date: 2000-04-20 Completed Date: 2000-04-20 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8710219 Medline TA: AIDS Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 103-8 Citation Subset: IM; X |
Affiliation:
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Department of Immunology, Westmead Hospital, University of Sydney, Australia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acquired Immunodeficiency Syndrome
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genetics* Genotype HIV Long-Term Survivors HIV-1* Heterozygote Homozygote Humans Mutation Polymerase Chain Reaction Polymorphism, Genetic Polymorphism, Restriction Fragment Length Promoter Regions, Genetic Prospective Studies Receptors, CCR2 Receptors, CCR5 / genetics* Receptors, Chemokine* Receptors, Cytokine / genetics |
| Chemical | |
Reg. No./Substance:
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0/CCR2 protein, human; 0/Receptors, CCR2; 0/Receptors, CCR5; 0/Receptors, Chemokine; 0/Receptors, Cytokine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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