Document Detail


CCR5 chemokine receptors: gatekeepers of HIV-1 infection.
MedLine Citation:
PMID:  12462129     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
With the discovery that CCR5 is the critical protein required for infection by M-tropic HIV, has come huge research efforts, both in academia and industry, to try to exploit this finding. Thus, research advances in the fields of virology, structural protein chemistry, and receptor pharmacology have combined to add a new understanding to the process of HIV fusion and possible mechanisms to prevent HIV entry. This review will approach this field from a receptor pharmacology viewpoint and outline some concepts of receptor allosterism and protein-protein interaction which may be relevant to CCR5 blockade. Many of these ideas may be explored in a practical sense with the advent of new small molecule CCR5 inhibitors currently entering the clinic.
Authors:
Wieslaw M Kazmierski; Larry Boone; Wendell Lawrence; Chris Watson; Terry Kenakin
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current drug targets. Infectious disorders     Volume:  2     ISSN:  1568-0053     ISO Abbreviation:  Curr Drug Targets Infect Disord     Publication Date:  2002 Sep 
Date Detail:
Created Date:  2002-12-03     Completed Date:  2002-12-19     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  101128002     Medline TA:  Curr Drug Targets Infect Disord     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  265-78     Citation Subset:  IM    
Affiliation:
Department of Medicinal Chemistry, GlaxoSmithKline Research and Development, 5 Moore Drive, Research Triangle Park, NC 27709, USA.
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MeSH Terms
Descriptor/Qualifier:
Acquired Immunodeficiency Syndrome / drug therapy*
Anti-HIV Agents / pharmacology*
Dimerization
Endocytosis
HIV-1 / drug effects*
Receptors, CCR5 / antagonists & inhibitors*,  chemistry,  metabolism
Viral Envelope Proteins / metabolism
Chemical
Reg. No./Substance:
0/Anti-HIV Agents; 0/Receptors, CCR5; 0/Viral Envelope Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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