| CCR3 antagonists: a survey of the patent literature. | |
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MedLine Citation:
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PMID: 19637977 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Since the mid-1990s, there has been significant effort invested in the discovery and clinical development of CC chemokine receptor-3 (CCR3) antagonists as potential therapeutics for airway disease. OBJECTIVES/METHODS: A patent literature review is presented of small molecule CCR3 antagonists comprising the years 2004 to the present. The patent searches were conducted using Derwent Discovery (World patent index) and PCT publication databases. RESULTS/CONCLUSION: At least two small molecule compounds have been reported to advance into clinical trials. However, data that support a definitive proof-of-concept in humans have yet to be disclosed. Nevertheless, patents from various pharmaceutical companies have continued to emerge, revealing diverse chemical classes of potent CCR3 antagonists and reflecting a continued broad interest in this area. |
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Authors:
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Leyi Gong; Robert S Wilhelm |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Expert opinion on therapeutic patents Volume: 19 ISSN: 1744-7674 ISO Abbreviation: Expert Opin Ther Pat Publication Date: 2009 Aug |
Date Detail:
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Created Date: 2009-07-29 Completed Date: 2009-11-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9516419 Medline TA: Expert Opin Ther Pat Country: England |
Other Details:
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Languages: eng Pagination: 1109-32 Citation Subset: IM |
Affiliation:
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Department of Medicinal Chemistry, Roche Palo Alto LLC, Palo Alto, CA 94304, USA. leyi.gong@roche.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Humans Interleukin-5 / antagonists & inhibitors Morpholines / pharmacology Patents as Topic* Piperidines / pharmacology Pyrrolidines / pharmacology Receptors, CCR3 / antagonists & inhibitors* |
| Chemical | |
Reg. No./Substance:
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0/Interleukin-5; 0/Morpholines; 0/Piperidines; 0/Pyrrolidines; 0/Receptors, CCR3 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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