| CCR2-64I allele is associated with the progression of AIDS in a Han Chinese population. | |
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MedLine Citation:
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PMID: 19669591 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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It has been reported that the CCR5-Delta32, CCR2-64I and SDF1-3'A polymorphisms have protective effects against HIV-1 infection and can delay the progression of AIDS in European populations. The aim of this study was to investigate the associations of the three loci with HIV-1 infection and the progression of AIDS in the Han population of northern China. We recruited 78 HIV-1-seropositive individuals and 70 population-matched healthy controls from north China. PCR-RFLP was used to genotype these three polymorphisms in all samples. There were no significant differences in the frequencies of any allele between HIV-1-seropositive individuals and healthy controls. In cases, the associations between the three loci and CD4(+) T-lymphocyte counts were not significant; however, there was a significant association between the genotype frequency of CCR2-64I and clinical category (P < 0.05). We have identified a potentially important role of CCR2-64I allele in AIDS progression in the northern Chinese population. Further studies are necessary to clarify the contribution of the CCR2-64I allele to the progression of AIDS for the relatively small sample size. |
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Authors:
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Lidan Xu; Yuandong Qiao; Xuelong Zhang; Haiming Sun; Jingwei Wang; Donglin Sun; Yan Jin; Yang Yu; Feng Chen; Jing Bai; Hong Ling; Kaili Wang; Songbin Fu |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-08-08 |
Journal Detail:
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Title: Molecular biology reports Volume: 37 ISSN: 1573-4978 ISO Abbreviation: Mol. Biol. Rep. Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-01-05 Completed Date: 2010-03-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0403234 Medline TA: Mol Biol Rep Country: Netherlands |
Other Details:
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Languages: eng Pagination: 311-6 Citation Subset: IM |
Affiliation:
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Laboratory of Medical Genetics, Harbin Medical University, Harbin, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acquired Immunodeficiency Syndrome
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genetics* Adult Aged Aged, 80 and over Alleles* Asian Continental Ancestry Group / genetics* Case-Control Studies China Disease Progression* Ethnic Groups / genetics* Genetic Predisposition to Disease* Humans Middle Aged Young Adult |
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