Document Detail

CCNU and bleomycin in the treatment of cancer: a Southwest Oncology Group Study.
MedLine Citation:
PMID:  59307     Owner:  NLM     Status:  MEDLINE    
CCNU and Bleomycin, alone or in combination, were used to treat 397 evaluable cases of advanced cancer. Responses defined as 50% or greater reduction in all tumor masses occurred in 13/35 lymphomas, 8/50 brain cancers, and 28/312 other solid tumors. Hematologic toxicity of a life-threatening degree occurred in 33/298 patients evaluable for CCNU toxicity; in an additional 50 it was considered severe. Pulmonary toxicity was severe in 4 patients. Drug-associated deaths (4) included one each due to leukopenia and thrombocytopenia after CCNU; one due to pulmonary toxicity after Bleomycin; and one due to shock after the 20th dose of Bleomycin. There was no suggestion of synergism or additive activity with the two drugs.
B Hoogstraten; C D Haas; A Haut; R W Talley; S Rivkin; B L Isaacs
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Medical and pediatric oncology     Volume:  1     ISSN:  0098-1532     ISO Abbreviation:  Med. Pediatr. Oncol.     Publication Date:  1975  
Date Detail:
Created Date:  1976-09-01     Completed Date:  1976-09-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7506654     Medline TA:  Med Pediatr Oncol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  95-106     Citation Subset:  IM    
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MeSH Terms
Adenocarcinoma / drug therapy
Bleomycin / administration & dosage,  therapeutic use*,  toxicity
Bone Marrow Cells
Carcinoma, Squamous Cell / drug therapy
Dose-Response Relationship, Drug
Drug Therapy, Combination
Injections, Intramuscular
Injections, Intravenous
Leukocyte Count
Lomustine / administration & dosage,  therapeutic use*,  toxicity
Lymphoma / drug therapy
Neoplasms / drug therapy*
Nitrosourea Compounds / therapeutic use*
Remission, Spontaneous
Time Factors
Reg. No./Substance:
0/Nitrosourea Compounds; 11056-06-7/Bleomycin; 13010-47-4/Lomustine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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