| CCL25 induces α(4) β(7) integrin-dependent migration of IL-17(+) γδ T lymphocytes during an allergic reaction. | |
| | |
MedLine Citation:
|
PMID: 22539297 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Herein, we provide evidence that during allergic inflammation, CCL25 induces the selec-tive migration of IL-17(+) γδ T cells mediated by α(4) β(7) integrin. Intrapleural injection of CCL25 into ovalbumin (OVA)-immunized C57BL/6 mice triggered the accumulation of γδ T lymphocytes expressing CCR9 (CCL25 receptor) and α(4) β(7) integrin in the pleura, but failed to attract αβ T lymphocytes. CCL25 attracted CCR6(+) γδ T cells producing IL-17 (but not IFN-γ or IL-4). OVA challenge triggered increased production of CCL25 followed by the accumulation of CCR9(+) , α(4) β(7) (+) , and CCR6(+) /IL-17(+) γδ T cells into the pleural cavities of OVA-immunized mice, which was inhibited by the in vivo neutralization of CCL25. The in vivo blockade of α(4) β(7) integrin also inhibited the migration of IL-17(+) γδ T lymphocytes (but not of αβ T lymphocytes) into mouse pleura after OVA challenge, suggesting that the CCL25/α(4) β(7) integrin pathway is selective for γδ T cells. In addition, α(4) β(7) integrin blockade impaired the in vitro transmigration of γδ T cells across endothelium (which expresses α(4) β(7) ligands VCAM-1 and MadCAM-1), which was induced by CCL25 and by cell-free pleural washes recovered from OVA-challenged mice. Our results reveal that during an allergic reaction, CCL25 drives IL-17(+) γδ T-cell mobilization to inflamed tissue via α(4) β(7) integrin and modulates IL-17 levels. |
| | |
Authors:
|
Maria F S Costa; Victor U Bornstein; André L Candéa; Andréa Henriques-Pons; Maria G Henriques; Carmen Penido |
Related Documents
:
|
22910767 - Targeting the microenvironment in chronic lymphocytic leukemia offers novel therapeutic... 11956167 - Establishment of cell lines with rat spermatogonial stem cell characteristics. 22862177 - Stem cell based glioblastoma gene therapy. 22550507 - Derivation of neural progenitors and retinal pigment epithelium from common marmoset an... 1972657 - T lymphocyte heterogeneity in the rat. iii. autoreactive t cells are activated by b cells. 8876607 - The gray zone between malignant and reactive processes in lymphoproliferative diseases. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: European journal of immunology Volume: 42 ISSN: 1521-4141 ISO Abbreviation: Eur. J. Immunol. Publication Date: 2012 May |
Date Detail:
|
Created Date: 2012-04-27 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 1273201 Medline TA: Eur J Immunol Country: Germany |
Other Details:
|
Languages: eng Pagination: 1250-60 Citation Subset: IM |
Copyright Information:
|
© 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
Affiliation:
|
Laboratório de Farmacologia Aplicada, Farmanguinhos, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Foxp3-independent loss of regulatory CD4+ T-cell suppressive capacities induced by self-deprivation.
Next Document: NKp46 expression discriminates porcine NK cells with different functional properties.