| CCL21 is sufficient to mediate DC migration, maturation and function in the absence of CCL19. | |
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MedLine Citation:
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PMID: 20201039 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Mice deficient in CCR7 signals show severe defects in lymphoid tissue architecture and immune response. These defects are due to impaired attraction of CCR7+ DC and CCR7+ T cells into the T zones of secondary lymphoid organs and altered DC maturation. It is currently unclear which CCR7 ligand mediates these processes in vivo as CCL19 and CCL21 show an overlapping expression pattern and blocking experiments have given contradictory results. In this study, we addressed this question using CCL19-deficient mice expressing various levels of CCL21. Complete deficiency of CCL19 and CCL21 but not CCL19 alone was found to be associated with abnormal frequencies and localization of DC in na?ve LN. Similarly, CCL19 was not required for DC migration from the skin, full DC maturation and efficient T-cell priming. Our findings suggest that CCL21 is the critical CCR7 ligand regulating DC homeostasis and function in vivo with CCL19 being redundant for these processes. |
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Authors:
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Mirjam R Britschgi; St?phanie Favre; Sanjiv A Luther |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European journal of immunology Volume: 40 ISSN: 1521-4141 ISO Abbreviation: Eur. J. Immunol. Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-05-04 Completed Date: 2010-06-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 1273201 Medline TA: Eur J Immunol Country: Germany |
Other Details:
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Languages: eng Pagination: 1266-71 Citation Subset: IM |
Affiliation:
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Department of Biochemistry, University of Lausanne, Epalinges, Switzerland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alleles Animals Bone Marrow Cells / cytology, immunology Cell Differentiation / physiology Cell Movement / physiology Chemokine CCL19 / deficiency, genetics, physiology* Chemokine CCL21 / biosynthesis, deficiency, genetics, physiology* Dendritic Cells / cytology*, immunology, transplantation Gene Dosage Gene Expression Regulation Lymph Nodes / cytology, immunology Lymphocyte Activation Mice Mice, Inbred C57BL Mice, Mutant Strains Receptors, CCR7 / physiology* Skin / cytology, immunology Specific Pathogen-Free Organisms T-Lymphocytes / immunology |
| Chemical | |
Reg. No./Substance:
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0/Ccl19 protein, mouse; 0/Ccl21a protein, mouse; 0/Ccr7 protein, mouse; 0/Chemokine CCL19; 0/Chemokine CCL21; 0/Receptors, CCR7 |
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