Document Detail

CCK(1) receptor is essential for normal meal patterning in mice fed high fat diet.
MedLine Citation:
PMID:  18023701     Owner:  NLM     Status:  MEDLINE    
Cholecystokinin (CCK), released by lipid in the intestine, initiates satiety by acting at cholecystokinin type 1 receptors (CCK(1)Rs) located on vagal afferent nerve terminals located in the wall of the gastrointestinal tract. In the present study, we determined the role of the CCK(1)R in the short term effects of a high fat diet on daily food intake and meal patterns using mice in which the CCK(1)R gene is deleted. CCK(1)R(-/-) and CCK(1)R(+/+) mice were fed isocaloric high fat (HF) or low fat (LF) diets ad libitum for 18 h each day and meal size, meal frequency, intermeal interval, and meal duration were determined. Daily food intake was unaltered by diet in the CCK(1)R(-/-) compared to CCK(1)R(+/+) mice. However, meal size was larger in the CCK(1)R(-/-) mice compared to CCK(1)R(+/+) mice when fed a HF diet, with a concomitant decrease in meal frequency. Meal duration was increased in mice fed HF diet regardless of phenotype. In addition, CCK(1)R(-/-) mice fed a HF diet had a 75% decrease in the time to 1st meal compared to CCK(1)R(+/+) mice following a 6 h fast. These data suggest that lack of the CCK(1)R results in diminished satiation, causing altered meal patterns including larger, less frequent meals when fed a high fat diet. These results suggest that the CCK(1)R is involved in regulating caloric intake on a meal to meal basis, but that other factors are responsible for regulation of daily food intake.
Michael J Donovan; Gabriel Paulino; Helen E Raybould
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Physiology & behavior     Volume:  92     ISSN:  0031-9384     ISO Abbreviation:  Physiol. Behav.     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-11-20     Completed Date:  2008-02-29     Revised Date:  2014-09-14    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  969-74     Citation Subset:  IM    
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MeSH Terms
Analysis of Variance
Behavior, Animal
Body Weight / drug effects,  genetics
Dietary Fats / pharmacology*
Eating / drug effects,  genetics
Feeding Behavior / drug effects*
Mice, Knockout
Reaction Time / drug effects,  genetics
Receptor, Cholecystokinin B / deficiency,  physiology*
Time Factors
Grant Support
Reg. No./Substance:
0/Dietary Fats; 0/Receptor, Cholecystokinin B

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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