Document Detail

CCK is involved in both peripheral and central mechanisms controlling food intake in chickens.
MedLine Citation:
PMID:  9039026     Owner:  NLM     Status:  MEDLINE    
The aim of this work was to study the involvement of cholecystokinin (CCK) in the control of food intake in chickens. The following aspects were studied: 1) the effects of intravenous and intracerebroventricular sulfated octapeptide of CCK (CCK-8s) on voluntary food intake; 2) the effects of two CCK-receptor antagonists. L-365,260 and L-364,718, on food intake; and 3) the ability of such drugs to block the effects of CCK-8s on food intake in the chicken. Intravenous and intracerebroventricular CCK-8s caused a decrease in food intake. Intraperitoneal L-365,260, a CCK-receptor antagonist with low affinity for the two CCK receptors described in the chicken, increases food intake. Intracerebroventricular L-364,718, a drug that has high affinity for the chicken central CCK-receptor type, increased food intake. The effect of intravenous CCK-8s on food intake was not blocked by L-364,718 or L-365,260, whereas that of intracerebroventricular CCK-8s was blocked by intracerebroventricular L-364,718. It is concluded that central endogenous CCK plays a role in the control of food intake, which is dependent on central CCK-receptor type; nevertheless, peripheral CCK also decreases food intake acting on the peripheral CCK-receptor type. The fact that intracerebroventricular L-364,718 is able to increase food intake is related to its high affinity for the central CCK-receptor type of this species. Finally, three different speculations that might explain the fact that intraperitoneal L-365,260 increases food intake are discussed.
A Rodríguez-Sinovas; E Fernández; X Manteca; A G Fernández; E Goñalons
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of physiology     Volume:  272     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1997 Jan 
Date Detail:
Created Date:  1997-03-31     Completed Date:  1997-03-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  R334-40     Citation Subset:  IM    
Department of Cell Biology and Physiology, Veterinary Faculty, Autonomous University of Barcelona, Bellaterra, Spain.
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MeSH Terms
Benzodiazepinones / pharmacology
Brain / physiology
Chickens / physiology*
Eating / drug effects*
Hormone Antagonists / pharmacology
Injections, Intravenous
Injections, Intraventricular
Phenylurea Compounds*
Receptors, Cholecystokinin / antagonists & inhibitors,  physiology
Sincalide / pharmacology*
Reg. No./Substance:
0/Benzodiazepinones; 0/Hormone Antagonists; 0/Phenylurea Compounds; 0/Receptors, Cholecystokinin; 103420-77-5/Devazepide; 118101-09-0/L 365260; 25126-32-3/Sincalide

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