Document Detail

CCK-8S facilitates 5-HT release in the rat hypothalamus.
MedLine Citation:
PMID:  9443553     Owner:  NLM     Status:  MEDLINE    
The effects of the neurotransmitter serotonin (5-HT) and the neuropeptide cholecystokinin (CCK) on food intake are well established. Based on pharmacological studies, an interactive model for 5-HT and CCK was proposed. The present microdialysis study was aimed to provide neurochemical evidence for a facilitatory effect of CCK-8S on 5-HT release in the lateral hypothalamus under in vivo conditions. The results indicate an increase of extracellular hypothalamic 5-HT both during food intake in previously food-deprived rats and also after systemic administration of 8 microg/kg and 40 microg/kg CCK-8s in food-deprived rats. The results show that peripherally administered CCK-8s induces central serotonergic effects, possibly related to feeding.
J P Voigt; R Sohr; H Fink
Related Documents :
16698143 - The effect of different macronutrient infusions on appetite, ghrelin and peptide yy in ...
8346313 - Modulation of the satiety effect of cholecystokinin by estradiol.
16479913 - Agricultural practices and personal hygiene among agricultural workers in a rural area ...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pharmacology, biochemistry, and behavior     Volume:  59     ISSN:  0091-3057     ISO Abbreviation:  Pharmacol. Biochem. Behav.     Publication Date:  1998 Jan 
Date Detail:
Created Date:  1998-03-09     Completed Date:  1998-03-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0367050     Medline TA:  Pharmacol Biochem Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  179-82     Citation Subset:  IM    
Institute of Pharmacology and Toxicology, Humboldt University, Berlin, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Anorexia / chemically induced
Feeding Behavior / physiology
Hypothalamic Area, Lateral / drug effects*,  metabolism
Rats, Wistar
Serotonin / metabolism*
Serotonin Agents / pharmacology*
Sincalide / analogs & derivatives*,  pharmacology
Reg. No./Substance:
0/8-sulfocholecystokinin octapeptide; 0/Serotonin Agents; 25126-32-3/Sincalide; 50-67-9/Serotonin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Forced swim test-induced endocrine and immune changes in the rat: effect of subacute desipramine tre...
Next Document:  Subacute Pb exposure during development and unbaited tunnel maze performance in mice.