Document Detail


CCK-8 and CCK-58 differ in their effects on nocturnal solid meal pattern in undisturbed rats.
MedLine Citation:
PMID:  22874423     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Various molecular forms of CCK reduce food intake in rats. Although CCK-8 is the most studied form, we reported that CCK-58 is the only detectable endocrine peptide form in rats. We investigated the dark-phase rat chow intake pattern following injection of CCK-8 and CCK-58. Ad libitum-fed male Sprague-Dawley rats were intraperitoneally injected with CCK-8, CCK-58 (0.6, 1.8, and 5.2 nmol/kg), or vehicle. Food intake pattern was assessed during the dark phase using an automated weighing system that allowed continuous undisturbed monitoring of physiological eating behavior. Both CCK-8 and CCK-58 dose dependently reduced 1-h, dark-phase food intake, with an equimolar dose of 1.8 nmol being similarly effective (-49% and -44%). CCK-58 increased the latency to the first meal, whereas CCK-8 did not. The intermeal interval was reduced after CCK-8 (1.8 nmol/kg, -41%) but not after CCK-58. At this dose, CCK-8 increased the satiety ratio by 80% and CCK-58 by 160%, respectively, compared with vehicle. When behavior was assessed manually, CCK-8 reduced locomotor activity (-31%), whereas grooming behavior was increased (+59%). CCK-58 affected neither grooming nor locomotor activity. In conclusion, reduction of food intake by CCK-8 and CCK-58 is achieved by differential modulation of food intake microstructure and behavior. These data highlight the importance of studying the molecular forms of peptides that exist in vivo in tissue and circulation of the animal being studied.
Authors:
Miriam Goebel-Stengel; Andreas Stengel; Lixin Wang; Gordon Ohning; Yvette Taché; Joseph R Reeve
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2012-08-08
Journal Detail:
Title:  American journal of physiology. Regulatory, integrative and comparative physiology     Volume:  303     ISSN:  1522-1490     ISO Abbreviation:  Am. J. Physiol. Regul. Integr. Comp. Physiol.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-16     Completed Date:  2012-12-21     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  100901230     Medline TA:  Am J Physiol Regul Integr Comp Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  R850-60     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cholecystokinin / administration & dosage*
Circadian Rhythm / drug effects*
Dose-Response Relationship, Drug
Eating / drug effects*
Feeding Behavior / drug effects*
Grooming / drug effects
Injections, Intraperitoneal
Male
Motor Activity / drug effects
Photoperiod
Rats
Rats, Sprague-Dawley
Reaction Time / drug effects
Satiety Response / drug effects
Sincalide / administration & dosage*
Time Factors
Grant Support
ID/Acronym/Agency:
DK-41301/DK/NIDDK NIH HHS; P30 DK041301/DK/NIDDK NIH HHS; R01 DK-083449/DK/NIDDK NIH HHS; R01 DK083449/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
83381-92-4/cholecystokinin 58; 9011-97-6/Cholecystokinin; M03GIQ7Z6P/Sincalide
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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