Document Detail


CCK-1 receptor blockade for treatment of biliary colic: a pilot study.
MedLine Citation:
PMID:  12895218     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Loxiglumide is a potent and selective cholecystokinin-1 (CCK-1) receptor antagonist able to inhibit gall-bladder contraction. AIM: To assess the effect of CCK-1 receptor blockade on the pain of patients with biliary colic. PATIENTS AND METHODS: Fourteen patients with biliary colic but no suspicion for acute cholecystitis, were randomly and blindly assigned to loxiglumide (50 mg i.v.) or hyoscine-N-butyl bromide (20 mg i.v.) treatment. Pain intensity was monitored by a Visual Analogue Scale. Patients with less than 80% response at 30 min, were retreated with a second injection of the same compound. RESULTS: Reduction in pain score (mean +/- S.E.M.) was faster and significantly greater in patients treated with loxiglumide (n = 7) than in controls (n = 7): 88 +/- 7% vs. 47 +/- 12% after 20 min, P < 0.05; 92 +/- 6% vs. 49 +/- 13%, after 30 min, P < 0.05. Only one of seven patients treated with loxiglumide needed a second injection at 30 min (vs. six of seven controls, P < 0.05). No adverse effect was observed after either treatment. CONCLUSIONS: Loxiglumide is highly effective in obtaining pain relief in patients with biliary colic. The analgesic effect of CCK-1 receptor blockade is superior to that of a conventional anticholinergic treatment.
Authors:
A Malesci; R Pezzilli; M D'Amato; L Rovati
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Alimentary pharmacology & therapeutics     Volume:  18     ISSN:  0269-2813     ISO Abbreviation:  Aliment. Pharmacol. Ther.     Publication Date:  2003 Aug 
Date Detail:
Created Date:  2003-08-04     Completed Date:  2003-10-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8707234     Medline TA:  Aliment Pharmacol Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  333-7     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, University of Milan, Milano, Italy. alberto.malesci@unimi.it
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Biliary Tract Diseases / drug therapy*
Colic / drug therapy*
Female
Humans
Male
Middle Aged
Pain Measurement
Pilot Projects
Proglumide / analogs & derivatives*,  therapeutic use*
Receptors, Cholecystokinin / antagonists & inhibitors*
Chemical
Reg. No./Substance:
0/Receptors, Cholecystokinin; 107097-80-3/loxiglumide; 6620-60-6/Proglumide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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