| CCK-1 receptor blockade for treatment of biliary colic: a pilot study. | |
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MedLine Citation:
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PMID: 12895218 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Loxiglumide is a potent and selective cholecystokinin-1 (CCK-1) receptor antagonist able to inhibit gall-bladder contraction. AIM: To assess the effect of CCK-1 receptor blockade on the pain of patients with biliary colic. PATIENTS AND METHODS: Fourteen patients with biliary colic but no suspicion for acute cholecystitis, were randomly and blindly assigned to loxiglumide (50 mg i.v.) or hyoscine-N-butyl bromide (20 mg i.v.) treatment. Pain intensity was monitored by a Visual Analogue Scale. Patients with less than 80% response at 30 min, were retreated with a second injection of the same compound. RESULTS: Reduction in pain score (mean +/- S.E.M.) was faster and significantly greater in patients treated with loxiglumide (n = 7) than in controls (n = 7): 88 +/- 7% vs. 47 +/- 12% after 20 min, P < 0.05; 92 +/- 6% vs. 49 +/- 13%, after 30 min, P < 0.05. Only one of seven patients treated with loxiglumide needed a second injection at 30 min (vs. six of seven controls, P < 0.05). No adverse effect was observed after either treatment. CONCLUSIONS: Loxiglumide is highly effective in obtaining pain relief in patients with biliary colic. The analgesic effect of CCK-1 receptor blockade is superior to that of a conventional anticholinergic treatment. |
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Authors:
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A Malesci; R Pezzilli; M D'Amato; L Rovati |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Alimentary pharmacology & therapeutics Volume: 18 ISSN: 0269-2813 ISO Abbreviation: Aliment. Pharmacol. Ther. Publication Date: 2003 Aug |
Date Detail:
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Created Date: 2003-08-04 Completed Date: 2003-10-07 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8707234 Medline TA: Aliment Pharmacol Ther Country: England |
Other Details:
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Languages: eng Pagination: 333-7 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, University of Milan, Milano, Italy. alberto.malesci@unimi.it |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Biliary Tract Diseases / drug therapy* Colic / drug therapy* Female Humans Male Middle Aged Pain Measurement Pilot Projects Proglumide / analogs & derivatives*, therapeutic use* Receptors, Cholecystokinin / antagonists & inhibitors* |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Cholecystokinin; 107097-80-3/loxiglumide; 6620-60-6/Proglumide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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