| CBP sensitizes v-myb-transformed monoblasts to differentiation inducers. | |
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MedLine Citation:
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PMID: 16026544 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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CREB-binding protein (CBP) regulates gene expression by binding to certain components of basal transcription machinery and by histone acetylation. In addition, it integrates various cellular signaling pathways through binding to multiple transcription factors, including the Myb proteins. We report in this study that CBP can partially suppress function of the v-Myb oncoprotein in leukemic cells. Although originally described as an activator of v-Myb function, we show that CBP can also act as a v-Myb suppressor. Ectopic expression of murine CBP in v-Myb-transformed chicken monoblasts reduced transcriptional activation abilities of the v-Myb protein and increased sensitivity to differentiation inducers such as phorbol ester or trichostatin A. In addition, exogenous CBP affected morphology of differentiated cells derived from BM2 monoblasts. These results indicate that cellular context is an important factor determining whether CBP will activate or suppress the protein it targets. |
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Authors:
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Jana Smardová; Alice Nemajerová; Jarmila Navrátilová; Pierre Jurdic; Jan Smarda |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Differentiation; research in biological diversity Volume: 73 ISSN: 0301-4681 ISO Abbreviation: Differentiation Publication Date: 2005 Jun |
Date Detail:
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Created Date: 2005-07-19 Completed Date: 2005-10-18 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0401650 Medline TA: Differentiation Country: England |
Other Details:
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Languages: eng Pagination: 222-32 Citation Subset: IM |
Affiliation:
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Department of Pathology and Anatomy, University Hospital, Jihlavská 20, 625 00 Brno, Czech Republic. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Avian myeloblastosis virus / physiology CREB-Binding Protein Cell Differentiation / drug effects, physiology* Cell Line, Transformed Cell Transformation, Viral / physiology Chickens Hydroxamic Acids / pharmacology Mice Monocytes / cytology, drug effects, physiology* Nuclear Proteins / genetics, physiology* Oncogene Proteins v-myb / physiology* Phagocytosis / physiology Phorbol Esters / pharmacology Trans-Activators / genetics, physiology* |
| Chemical | |
Reg. No./Substance:
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0/Crebbp protein, mouse; 0/Hydroxamic Acids; 0/Nuclear Proteins; 0/Oncogene Proteins v-myb; 0/Phorbol Esters; 0/Trans-Activators; 58880-19-6/trichostatin A; EC 2.3.1.48/CREB-Binding Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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