Document Detail


CB1 cannabinoid receptor activation inhibits a neural correlate of song recognition in an auditory/perceptual region of the zebra finch telencephalon.
MedLine Citation:
PMID:  12884265     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A notable consequence of CB1 cannabinoid receptor activation in vertebrates is an impairment of cognitive function related to learning and short-term memory. The mechanisms of this impairment remain unclear, but one possibility is that cannabinoids influence encoding of stimuli at sensory and/or perceptual levels. Here, by treating zebra finches with the cannabinoid agonist WIN55212-2 and then measuring expression of the transcription factor zenk following presentation of novel zebra finch song, we show that cannabinoid receptor activation differentially influences zenk expression in sensory versus perceptual regions of the songbird auditory telencephalon. That is, WIN55212-2 dose-dependently inhibited zenk expression in a region for auditory perception (NCM, the caudomedial neostriatum), but had no effect on zenk expression in the primary auditory area, the Field L complex. The inhibitory effects of WIN55212-2 on zenk expression in NCM were reversed by coadministration of the CB1-selective antagonist SR141716A. Moreover, we found that the habituation of the NCM zenk response to repeated presentation of the same song, a well-established neural correlate of song recognition, was blocked when birds were treated with WIN55212-2 during habituation trials. Our data suggest that activation of CB1 cannabinoid receptors can selectively influence perceptual and mnemonic aspects of auditory experience.
Authors:
Osceola Whitney; Ken Soderstrom; Frank Johnson
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of neurobiology     Volume:  56     ISSN:  0022-3034     ISO Abbreviation:  J. Neurobiol.     Publication Date:  2003 Sep 
Date Detail:
Created Date:  2003-07-28     Completed Date:  2003-09-17     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0213640     Medline TA:  J Neurobiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  266-74     Citation Subset:  IM    
Copyright Information:
Copyright 2003 Wiley Periodicals, Inc. J Neurobiol 56: 266-274, 2003
Affiliation:
Department of Psychology and Program in Neuroscience, Florida State University, Tallahassee, Florida 32306-1270, USA. owhitney@psy.fsu.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Auditory Perception / drug effects,  physiology*
Cannabinoids / metabolism,  pharmacology
Dose-Response Relationship, Drug
Neural Inhibition / physiology
Receptors, Cannabinoid
Receptors, Drug / agonists,  metabolism*
Recognition (Psychology) / physiology*
Songbirds
Telencephalon / drug effects,  metabolism*
Vocalization, Animal / physiology*
Grant Support
ID/Acronym/Agency:
DA05986/DA/NIDA NIH HHS; DC02035/DC/NIDCD NIH HHS
Chemical
Reg. No./Substance:
0/Cannabinoids; 0/Receptors, Cannabinoid; 0/Receptors, Drug

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