Document Detail

CB 1954 (2,4-dinitro-5-aziridinyl benzamide) becomes a DNA interstrand crosslinking agent in Walker tumour cells.
MedLine Citation:
PMID:  3778483     Owner:  NLM     Status:  MEDLINE    
Walker tumour cells were shown to be uniquely sensitive to CB 1954 when compared with other cells in vitro. CB 1954 forms DNA-DNA interstrand crosslinks in a time-dependent manner in Walker tumour but not Chinese hamster cells. The absence of interstrand crosslinks in hamster cells was not due to a lack of uptake of drug but rather to a failure to convert (probably by bioreduction) CB 1954 to the required reactive difunctional intermediate.
J J Roberts; F Friedlos; R J Knox
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  140     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  1986 Nov 
Date Detail:
Created Date:  1986-12-18     Completed Date:  1986-12-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1073-8     Citation Subset:  IM    
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MeSH Terms
Antineoplastic Agents / metabolism,  pharmacology*
Aziridines / metabolism,  pharmacology*
Azirines / pharmacology*
Carcinoma 256, Walker / metabolism*
Cell Survival / drug effects
Cross-Linking Reagents*
DNA, Neoplasm / drug effects*
Reg. No./Substance:
0/Antineoplastic Agents; 0/Aziridines; 0/Azirines; 0/Cross-Linking Reagents; 0/DNA, Neoplasm; 21919-05-1/5-(1-aziridinyl)-2,4-dinitrobenzamide

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