| CB 1954 (2,4-dinitro-5-aziridinyl benzamide) becomes a DNA interstrand crosslinking agent in Walker tumour cells. | |
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MedLine Citation:
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PMID: 3778483 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Walker tumour cells were shown to be uniquely sensitive to CB 1954 when compared with other cells in vitro. CB 1954 forms DNA-DNA interstrand crosslinks in a time-dependent manner in Walker tumour but not Chinese hamster cells. The absence of interstrand crosslinks in hamster cells was not due to a lack of uptake of drug but rather to a failure to convert (probably by bioreduction) CB 1954 to the required reactive difunctional intermediate. |
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Authors:
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J J Roberts; F Friedlos; R J Knox |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biochemical and biophysical research communications Volume: 140 ISSN: 0006-291X ISO Abbreviation: Biochem. Biophys. Res. Commun. Publication Date: 1986 Nov |
Date Detail:
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Created Date: 1986-12-18 Completed Date: 1986-12-18 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1073-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antineoplastic Agents / metabolism, pharmacology* Aziridines / metabolism, pharmacology* Azirines / pharmacology* Carcinoma 256, Walker / metabolism* Cell Survival / drug effects Cricetinae Cricetulus Cross-Linking Reagents* DNA, Neoplasm / drug effects* Rats |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/Aziridines; 0/Azirines; 0/Cross-Linking Reagents; 0/DNA, Neoplasm; 21919-05-1/5-(1-aziridinyl)-2,4-dinitrobenzamide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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