Document Detail


CART peptide following social novelty in the prairie vole (Microtus ochrogaster).
MedLine Citation:
PMID:  21871610     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Prairie voles (Microtus ochrogaster) are monogamous rodents that display high levels of affiliative behaviors, including pair-bonding, biparental care, and cooperative breeding. Species differences in basal cocaine- and amphetamine-regulated transcript (CART) mRNA and peptide expression have been found between prairie voles and polygamous meadow voles. Therefore, we hypothesized that the CART system may play a role in the regulation of social behavior in this species. Male and female adult prairie voles were placed in a cage either alone, or with a novel social partner of the same or opposite sex. After 45 min, subjects were sacrificed and CART peptide expression was examined using immunohistochemistry. We examined fifteen hypothalamic, limbic, and hindbrain regions of interest, focusing on areas that show species-specific patterns of expression. We found that subjects paired with a novel conspecific had lower levels of peptide in the bed nucleus of the stria terminalis (BNST) than isolated animals. This may reflect increased peptide release following increased dopaminergic activity in animals exposed to a novel conspecific. Additionally, CART peptide was higher in the nucleus accumbens (NAc) of subjects paired with an opposite sex partner compared to those paired with a same-sex conspecific, although there was no difference between isolated subjects and either socially housed group. These findings suggest that CART in the NAc is differentially responsive to the sex of adult conspecifics and that the social environment influences CART expression in the prairie vole in a region- and stimulus-specific manner.
Authors:
Caroline M Hostetler; Alex S Kowalczyk; Luana L Griffin; Karen L Bales
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-07-24
Journal Detail:
Title:  Brain research     Volume:  1414     ISSN:  1872-6240     ISO Abbreviation:  Brain Res.     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-09-19     Completed Date:  2012-01-18     Revised Date:  2014-09-19    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  32-40     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier B.V. All rights reserved.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Animals
Animals, Newborn
Arvicolinae / physiology*
Brain / anatomy & histology,  metabolism
Corticotropin-Releasing Hormone / metabolism
Dopamine / metabolism
Exploratory Behavior / physiology*
Female
Male
Nerve Tissue Proteins / genetics,  metabolism*
Pair Bond*
RNA, Messenger / metabolism
Sex Factors
Social Behavior*
Species Specificity
Grant Support
ID/Acronym/Agency:
MH073022/MH/NIMH NIH HHS; R01 MH073022/MH/NIMH NIH HHS; R01 MH073022-01A1/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
0/Nerve Tissue Proteins; 0/RNA, Messenger; 0/cocaine- and amphetamine-regulated transcript protein; 9015-71-8/Corticotropin-Releasing Hormone; VTD58H1Z2X/Dopamine
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Prioritization and association analysis of murine-derived candidate genes in anxiety-spectrum disord...
Next Document:  Event-related brain responses as correlates of changes in predictive and affective values of conditi...