Document Detail


The CARDS trial: diabetic patients dealt a winning hand.
MedLine Citation:
PMID:  16901414     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Until recently, the role of statin therapy in diabetic patients without clinical signs or symptoms of coronary heart disease had been inadequately defined. The Collaborative Atorvastatin Diabetes Study (CARDS) is a prospective, randomized, placebo-controlled trial designed to compare the effects of atorvastatin with placebo in preventing primary coronary events in diabetic patients. After a median of only 3.9 years (the study was terminated approximately 2 years early due to the magnitude of benefit attributable to atorvastatin therapy), risk for major cardiovascular events was decreased by 37%, acute coronary heart disease-related events were also reduced by 36%, coronary revascularizations by 31%, and stroke by 48%. Benefit emerged within 1 year of initiating therapy.
Authors:
Annemarie Armani; Peter P Toth
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Publication Detail:
Type:  Journal Article; Multicenter Study; Randomized Controlled Trial    
Journal Detail:
Title:  Current atherosclerosis reports     Volume:  8     ISSN:  1523-3804     ISO Abbreviation:  Curr Atheroscler Rep     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-08-11     Completed Date:  2006-12-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100897685     Medline TA:  Curr Atheroscler Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  429-32     Citation Subset:  IM    
Affiliation:
Sterling Rock Falls Clinic, 101 East Miller Road, Sterling, IL 61081, USA.
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MeSH Terms
Descriptor/Qualifier:
Cardiovascular Diseases / blood,  etiology,  prevention & control*
Cholesterol, LDL / blood*,  drug effects
Diabetes Mellitus, Type 2 / blood,  complications*
Follow-Up Studies
Heptanoic Acids / therapeutic use*
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use*
Primary Prevention / methods
Prospective Studies
Pyrroles / therapeutic use*
Risk Factors
Treatment Outcome
Chemical
Reg. No./Substance:
0/Cholesterol, LDL; 0/Heptanoic Acids; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 0/Pyrroles; 110862-48-1/atorvastatin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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