Document Detail

The CARDS trial: diabetic patients dealt a winning hand.
MedLine Citation:
PMID:  16901414     Owner:  NLM     Status:  MEDLINE    
Until recently, the role of statin therapy in diabetic patients without clinical signs or symptoms of coronary heart disease had been inadequately defined. The Collaborative Atorvastatin Diabetes Study (CARDS) is a prospective, randomized, placebo-controlled trial designed to compare the effects of atorvastatin with placebo in preventing primary coronary events in diabetic patients. After a median of only 3.9 years (the study was terminated approximately 2 years early due to the magnitude of benefit attributable to atorvastatin therapy), risk for major cardiovascular events was decreased by 37%, acute coronary heart disease-related events were also reduced by 36%, coronary revascularizations by 31%, and stroke by 48%. Benefit emerged within 1 year of initiating therapy.
Annemarie Armani; Peter P Toth
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Publication Detail:
Type:  Journal Article; Multicenter Study; Randomized Controlled Trial    
Journal Detail:
Title:  Current atherosclerosis reports     Volume:  8     ISSN:  1523-3804     ISO Abbreviation:  Curr Atheroscler Rep     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-08-11     Completed Date:  2006-12-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100897685     Medline TA:  Curr Atheroscler Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  429-32     Citation Subset:  IM    
Sterling Rock Falls Clinic, 101 East Miller Road, Sterling, IL 61081, USA.
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MeSH Terms
Cardiovascular Diseases / blood,  etiology,  prevention & control*
Cholesterol, LDL / blood*,  drug effects
Diabetes Mellitus, Type 2 / blood,  complications*
Follow-Up Studies
Heptanoic Acids / therapeutic use*
Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use*
Primary Prevention / methods
Prospective Studies
Pyrroles / therapeutic use*
Risk Factors
Treatment Outcome
Reg. No./Substance:
0/Cholesterol, LDL; 0/Heptanoic Acids; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 0/Pyrroles; 110862-48-1/atorvastatin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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