Document Detail

CARDIAC role of the mitochondrial Ca2+ transporters in the high-[K+](o) cardioprotection of rat hearts under ischemia and reperfusion: a mechano-energetic study.
MedLine Citation:
PMID:  19597370     Owner:  NLM     Status:  MEDLINE    
CONCLUSIONS: Mitochondria have a precise role for determining cardioprotection or stunning in high-K+ cardioplegic rat hearts under I/R. Known protective drugs, such as Dzx and Ru360, which reduce the mitochondrial Ca2+-uptake, increased the stunning of CPG-rat hearts and reduced muscle economy, whereas 5-hydroxydecanoate and Clzp together increased the stunning by inducing mitochondrial Ca2+ overload.
María Inés Ragone; Alicia E Consolini
Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  54     ISSN:  1533-4023     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2010-05-06     Completed Date:  2010-08-18     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  213-22     Citation Subset:  IM    
Cátedra de Farmacología, Area Farmacia, Departamento de Ciencias Biológicas, Facultad de Ciencias Exactas, Universidad Nacional de La Plata (UNLP), Argentina.
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MeSH Terms
Calcium Channel Agonists / pharmacology
Calcium Channel Blockers / pharmacology
Calcium Channels / metabolism*
Cardioplegic Solutions
Heart / drug effects,  physiopathology*
Heart Arrest, Induced
Heart Rate / drug effects
Mitochondria, Heart / drug effects,  enzymology*,  physiology*
Mitochondrial Membrane Transport Proteins / antagonists & inhibitors
Myocardial Reperfusion Injury / physiopathology*
Myocardial Stunning / chemically induced
Potassium Channel Blockers / pharmacology
Potassium Channels / agonists
Rats, Sprague-Dawley
Sodium-Calcium Exchanger / antagonists & inhibitors
Time Factors
Ventricular Pressure / drug effects
Reg. No./Substance:
0/Calcium Channel Agonists; 0/Calcium Channel Blockers; 0/Calcium Channels; 0/Cardioplegic Solutions; 0/Mitochondrial Membrane Transport Proteins; 0/Potassium Channel Blockers; 0/Potassium Channels; 0/Sodium-Calcium Exchanger; 0/mitochondrial calcium uniporter; 0/mitochondrial permeability transition pore

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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