| CARD8 p.C10X polymorphism is associated with inflammatory activity in early rheumatoid arthritis. | |
| | |
MedLine Citation:
|
PMID: 19443463 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVES: CARD8 and NLRP3 are constituents of the inflammasome which regulates interleukin 1beta production. The influence of polymorphisms in CARD8 and NLRP3 on rheumatoid arthritis (RA) susceptibility and severity were evaluated. METHODS: CARD8 p.C10X and NLRP3 p.Q705K genotypes were assessed in >500 controls and patients with early RA from northern Sweden. The patients were monitored regularly over a 2-year period. The 28-joint disease activity score (DAS28) and its separate components were compared across genotypes. RESULTS: Patients with one or more variant alleles in CARD8 (CARD8-X) had increased DAS28, tender joint count and erythrocyte sedimentation rate during the 2-year follow-up period despite receiving disease-modifying antirheumatic drugs to a greater extent. CARD8-X was significantly over-represented among patients who received anti-tumour necrosis factor therapy during the first 2 years. CARD8 and NLRP3 genotypes did not influence radiological joint damage and were not associated with an increased susceptibility. CONCLUSIONS: Carriage of CARD8-X is associated with a worse disease course in early RA. |
| | |
Authors:
|
Alf Kastbom; Martin Johansson; Deepti Verma; Peter S?derkvist; Solbritt Rantap??-Dahlqvist |
Related Documents
:
|
12164803 - B cells and immunoglobulins dependent mechanisms in rheumatoid arthritis: a possible ra... 17474133 - Myeloperoxidase and chlorinated peptides in osteoarthritis: potential biomarkers of the... 10022633 - Gastric emptying of solids in long-term nsaid users: correlation with endoscopic findin... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-05-13 |
Journal Detail:
|
Title: Annals of the rheumatic diseases Volume: 69 ISSN: 1468-2060 ISO Abbreviation: Ann. Rheum. Dis. Publication Date: 2010 Apr |
Date Detail:
|
Created Date: 2010-03-18 Completed Date: 2010-04-16 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0372355 Medline TA: Ann Rheum Dis Country: England |
Other Details:
|
Languages: eng Pagination: 723-6 Citation Subset: IM |
Affiliation:
|
Division of Rheumatology, Link?ping University Hospital, Link?ping, Sweden. alf.kastbom@liu.se |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Antirheumatic Agents / therapeutic use Arthritis, Rheumatoid / blood, drug therapy, genetics* Blood Sedimentation CARD Signaling Adaptor Proteins / genetics* Carrier Proteins / genetics Disease Progression Epidemiologic Methods Female Genetic Predisposition to Disease Genotype Humans Male Middle Aged Neoplasm Proteins / genetics* Polymorphism, Genetic* |
| Chemical | |
Reg. No./Substance:
|
0/Antirheumatic Agents; 0/CARD Signaling Adaptor Proteins; 0/CARD8 protein, human; 0/Carrier Proteins; 0/NLRP3 protein, human; 0/Neoplasm Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Ranibizumab (Lucentis) in neovascular age-related macular degeneration: evidence from clinical trial...
Next Document: New surfactant protein C gene mutations associated with diffuse lung disease.