Document Detail

CARD8 p.C10X polymorphism is associated with inflammatory activity in early rheumatoid arthritis.
MedLine Citation:
PMID:  19443463     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: CARD8 and NLRP3 are constituents of the inflammasome which regulates interleukin 1beta production. The influence of polymorphisms in CARD8 and NLRP3 on rheumatoid arthritis (RA) susceptibility and severity were evaluated. METHODS: CARD8 p.C10X and NLRP3 p.Q705K genotypes were assessed in >500 controls and patients with early RA from northern Sweden. The patients were monitored regularly over a 2-year period. The 28-joint disease activity score (DAS28) and its separate components were compared across genotypes. RESULTS: Patients with one or more variant alleles in CARD8 (CARD8-X) had increased DAS28, tender joint count and erythrocyte sedimentation rate during the 2-year follow-up period despite receiving disease-modifying antirheumatic drugs to a greater extent. CARD8-X was significantly over-represented among patients who received anti-tumour necrosis factor therapy during the first 2 years. CARD8 and NLRP3 genotypes did not influence radiological joint damage and were not associated with an increased susceptibility. CONCLUSIONS: Carriage of CARD8-X is associated with a worse disease course in early RA.
Alf Kastbom; Martin Johansson; Deepti Verma; Peter S?derkvist; Solbritt Rantap??-Dahlqvist
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-05-13
Journal Detail:
Title:  Annals of the rheumatic diseases     Volume:  69     ISSN:  1468-2060     ISO Abbreviation:  Ann. Rheum. Dis.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-18     Completed Date:  2010-04-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372355     Medline TA:  Ann Rheum Dis     Country:  England    
Other Details:
Languages:  eng     Pagination:  723-6     Citation Subset:  IM    
Division of Rheumatology, Link?ping University Hospital, Link?ping, Sweden.
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MeSH Terms
Antirheumatic Agents / therapeutic use
Arthritis, Rheumatoid / blood,  drug therapy,  genetics*
Blood Sedimentation
CARD Signaling Adaptor Proteins / genetics*
Carrier Proteins / genetics
Disease Progression
Epidemiologic Methods
Genetic Predisposition to Disease
Middle Aged
Neoplasm Proteins / genetics*
Polymorphism, Genetic*
Reg. No./Substance:
0/Antirheumatic Agents; 0/CARD Signaling Adaptor Proteins; 0/CARD8 protein, human; 0/Carrier Proteins; 0/NLRP3 protein, human; 0/Neoplasm Proteins

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