Document Detail


The CAG regimen (low-dose cytarabine, aclarubicin hydrochloride and granulocyte colony-stimulating factor) for the treatment of elderly acute myelomonocytic leukaemia: a case study.
MedLine Citation:
PMID:  11277347     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Elderly patients with acute myelomonocytic leukaemia (AMMoL) frequently have a poor quality of life after induction of remission using high-intensity treatment; we seek a more appropriate regimen for such patients. An 86-year-old man was hospitalized with a diagnosis of AMMoL (FAB classification M4), of abnormal karyotype, and complications of diabetes mellitus and complete right bundle branch block. He was treated with CAG therapy (cytarabine 10 mg/m2 subcutaneously every 12 h for 14 consecutive days; aclarubicin hydrochloride 10 mg/m2 per day, bolus intravenously for 4 consecutive days; granulocyte colony-stimulating factor 100 microg/day, subcutaneous injection for 14 consecutive days) every 3 months. White blood cell counts were at their lowest (around 600 - 800/microl) 12 days after the end of therapy, but returned to about 2000 - 2300/microl 30 days after stopping therapy. No symptoms of drug-related toxicity, except slight nausea, were found. Complete remission with a good quality of life was induced and lasted over 2 years suggesting that CAG therapy might prove effective in elderly patients with AMMoL.
Authors:
T Tsuda; Y Okamoto; R Sakaguchi; N Katayama; K Ota
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Journal of international medical research     Volume:  29     ISSN:  0300-0605     ISO Abbreviation:  J. Int. Med. Res.     Publication Date:    2001 Jan-Feb
Date Detail:
Created Date:  2001-03-29     Completed Date:  2001-07-19     Revised Date:  2006-04-24    
Medline Journal Info:
Nlm Unique ID:  0346411     Medline TA:  J Int Med Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  41-7     Citation Subset:  IM    
Affiliation:
Department of Blood Transfusion Medicine and Clinical Hematology, Wakayama Medical College, Wakayama City, Japan.
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MeSH Terms
Descriptor/Qualifier:
Aclarubicin / therapeutic use*
Aged
Aged, 80 and over
Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
Cytarabine / therapeutic use*
Granulocyte Colony-Stimulating Factor / therapeutic use*
Humans
Leukemia, Myelomonocytic, Acute / drug therapy*,  pathology
Male
Chemical
Reg. No./Substance:
0/CAG protocol; 143011-72-7/Granulocyte Colony-Stimulating Factor; 147-94-4/Cytarabine; 57576-44-0/Aclarubicin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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