Document Detail

CA 50 compared with CA 19-9 as a serum tumour marker for pancreatic carcinoma.
MedLine Citation:
PMID:  7949259     Owner:  NLM     Status:  MEDLINE    
This study compared the sensitivity and specificity of CA 50 and CA 19-9 as serum tumour markers for pancreatic cancer. One hundred and seventy one subjects were evaluated: 50 healthy controls, 50 patients with pancreatic carcinoma and 71 patients with chronic pancreatitis. Eighty per cent of the pancreatic cancer patients had raised CA 19-9 serum levels and 82% had raised CA 50 serum levels. In the group of patients ith chronic pancreatitis, false positive tests occurred in 8.4% for CA 19-9 and 11.3% for CA 50. For both markers the serum level showed a severe elevation in the advanced stage of cancer disease. Despite the good sensitivity and specificity of CA 50 as a serum tumour marker for pancreatic carcinoma, no major advantage was found compared to CA 19-9. Moreover, if the CA 50 cut-off, level is raised to 85 U/ml to exclude overlap with chronic pancreatitis, sensitivity falls sharply to 46% compared with 72% for CA 19-9 when a 100 U/ml cut-off level is used.
C Pasquali; C Sperti; A A D'Andrea; V Costantino; C Filipponi; S Pedrazzoli
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Italian journal of gastroenterology     Volume:  26     ISSN:  0392-0623     ISO Abbreviation:  Ital J Gastroenterol     Publication Date:  1994 May 
Date Detail:
Created Date:  1994-12-08     Completed Date:  1994-12-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8000544     Medline TA:  Ital J Gastroenterol     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  169-73     Citation Subset:  IM    
Istituto di Semeiotica Chirurgica, Università di Padova, Italy.
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MeSH Terms
Aged, 80 and over
Antigens, Tumor-Associated, Carbohydrate / blood*
CA-19-9 Antigen / blood*
Carcinoma, Acinar Cell / blood*,  diagnosis
Carcinoma, Ductal, Breast / blood*,  diagnosis
Chronic Disease
Cystadenocarcinoma / blood*,  diagnosis
Diagnosis, Differential
Middle Aged
Neoplasm Staging
Pancreatic Neoplasms / blood*,  diagnosis
Pancreatitis / blood*,  diagnosis
Predictive Value of Tests
Reproducibility of Results
Sensitivity and Specificity
Tumor Markers, Biological / blood*
Reg. No./Substance:
0/Antigens, Tumor-Associated, Carbohydrate; 0/CA-19-9 Antigen; 0/CA-50 antigen; 0/Tumor Markers, Biological

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